Kidney donation and transplantation in Iran has passed a long history from the first kidney transplant in 1967, starting living related transplant in 1988 to 1989, adopting state-regulated living-unrelated donor kidney transplant program in 1988, religious approval from the Supreme Religious Leader for brain death in 1989, legislation law for cadaveric transplant in 2000, and increased number of cadaveric transplants, which put the country ahead of all country members of the Middle East Society for Organ Transplantation in performing deceased donor kidney and liver transplants in 2011 to 2012.