Paper Information

Journal:   JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)   MAY 2014 , Volume 19 , Number 5; Page(s) 387 To 390.
 
Paper: 

INSULIN AND LEPTIN LEVELS IN OVERWEIGHT AND NORMAL-WEIGHT IRANIAN ADOLESCENTS: CASPIAN-III STUDY

 
 
Author(s):  BAHRAMI EHSAN, MIRMOGHTADAEE PARISA, ARDALAN GELAYOL, ZARKESH ESFAHANI HAMID, TAJADDINI MOHAMMAD HASSAN, HAGHJOOY JAVANMARD SHAGHAYEGH, NAJAFI HANANEH, KELISHADI ROYA*
 
* DEPARTMENTS OF PEDIATRICS, CHILD GROWTH AND DEVELOPMENT RESEARCH CENTER AND FACULTY OF MEDICINE, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, IRAN
 
Abstract: 

Background: In this study, we aim to compare insulin and leptin levels in adolescents with or without overweight and in those with or without abdominal obesity.
Materials and Methods: This case-control study was conducted among 486 samples. We randomly selected 243 overweight and an equal number of normal-weight adolescents from among participants of the third survey of a national surveillance program entitled “Childhood and Adolescence Surveillance and Prevention of Adult Non-communicable diseases study”. Serum insulin and leptin were compared between two groups and their correlation was determined with other variables.
Results: The mean age and body mass index (BMI) of participants were 14.10
±2.82 years and 22.12±6.49 kg/m2, respectively. Leptin and insulin levels were higher in overweight than in normal-weight adolescents (P<0.05). Leptin level was higher in children with abdominal obesity than in their other counterparts (P<0.001). Leptin level was correlated with age, fasting blood glucose, BMI, and insulin level.
Conclusion: Insulin and leptin levels were higher among overweight and obese children, which may reflect insulin and leptin-resistance. Given the complications of excess weight from early life, prevention and controlling childhood obesity should be considered as a health priority.

 
Keyword(s): CHILDREN, INSULIN, LEPTIN, OBESITY, OVERWEIGHT
 
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