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Paper Information

Journal:   IRANIAN JOURNAL OF NURSING AND MIDWIFERY RESEARCH (IJNMR)   NOVEMBER-DECEMBER 2013 , Volume 18 , Number 6; Page(s) 463 To 466.
 
Paper: 

SERUM LEVELS OF TUMOR NECROSIS FACTOR-α, INTERLEUKIN-15 AND INTERLEUKIN-10 IN PATIENTS WITH PRE-ECLAMPSIA IN COMPARISON WITH NORMOTENSIVE PREGNANT WOMEN

 
 
Author(s):  KALANTAR FATHOLLAH, RAJAEI SAMIRA, HEIDARI AMIR BEHZAD, MANSOURI REZA, RASHIDI NESA, HOSSEINALI IZAD MARYAM, MIRAHMADIAN MAHROO*
 
* DEPARTMENT OF IMMUNOLOGY, SCHOOL OF MEDICINE, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Background: Pre-eclampsia (PE) is a pregnancy associated disorder characterized by hyper-tension and proteinuria. The first 2 stages of PE cause dysfunction in uteroplacental perfusion and oxidative stress while the third stage of PE is due to the release of inflammatory and angiogenic factors, which could lead to maternal endothelial damage and systemic inflammatory response. In this study, we compared the serum levels of tumor necrosis factor-a (TNF-a), interleukin-15 (IL-15), and interleukin-10 (IL-10) in PE and normotensive women.
Materials and Methods: Serum samples of 84 pregnant women (44 PE and 40 normotensive) were evaluated for TNF-
a, IL-15 and IL-10 by sandwich ELISA assay.
Results: The women with PE showed significantly higher serum levels of TNF-
a and IL-15 (P=0.001 and 0.01 respectively) in comparison with normotensive pregnant women. Conversely, the serum levels of IL-10 in normotensive women were significantly higher compared to PE patients (P=0.01).
Conclusion: The results of this study demonstrated that inflammatory T helper 1-type responses are increased in PE women compared to normotensive pregnant women.

 
Keyword(s): INTERLEUKIN-10, INTERLEUKIN-15, PREECLAMPSIA, TUMOR NECROSIS FACTOR-α
 
 
References: 
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Click to Cite.
APA: Copy

KALANTAR, F., & RAJAEI, S., & HEIDARI, A., & MANSOURI, R., & RASHIDI, N., & HOSSEINALI IZAD, M., & MIRAHMADIAN, M. (2013). SERUM LEVELS OF TUMOR NECROSIS FACTOR-α, INTERLEUKIN-15 AND INTERLEUKIN-10 IN PATIENTS WITH PRE-ECLAMPSIA IN COMPARISON WITH NORMOTENSIVE PREGNANT WOMEN. IRANIAN JOURNAL OF NURSING AND MIDWIFERY RESEARCH (IJNMR), 18(6), 463-466. https://www.sid.ir/en/journal/ViewPaper.aspx?id=408749



Vancouver: Copy

KALANTAR FATHOLLAH, RAJAEI SAMIRA, HEIDARI AMIR BEHZAD, MANSOURI REZA, RASHIDI NESA, HOSSEINALI IZAD MARYAM, MIRAHMADIAN MAHROO. SERUM LEVELS OF TUMOR NECROSIS FACTOR-α, INTERLEUKIN-15 AND INTERLEUKIN-10 IN PATIENTS WITH PRE-ECLAMPSIA IN COMPARISON WITH NORMOTENSIVE PREGNANT WOMEN. IRANIAN JOURNAL OF NURSING AND MIDWIFERY RESEARCH (IJNMR). 2013 [cited 2021May15];18(6):463-466. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408749



IEEE: Copy

KALANTAR, F., RAJAEI, S., HEIDARI, A., MANSOURI, R., RASHIDI, N., HOSSEINALI IZAD, M., MIRAHMADIAN, M., 2013. SERUM LEVELS OF TUMOR NECROSIS FACTOR-α, INTERLEUKIN-15 AND INTERLEUKIN-10 IN PATIENTS WITH PRE-ECLAMPSIA IN COMPARISON WITH NORMOTENSIVE PREGNANT WOMEN. IRANIAN JOURNAL OF NURSING AND MIDWIFERY RESEARCH (IJNMR), [online] 18(6), pp.463-466. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408749.



 
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