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Paper Information

Journal:   BASIC AND CLINICAL NEUROSCIENCE   SPRING 2014 , Volume 5 , Number 2; Page(s) 138 To 143.
 
Paper: 

RILUZOLE AMELIORATES HARMALINE-INDUCED TREMOR IN RAT

 
 
Author(s):  RAHIMI SHOURMASTI FATEMEH*, GOUDARZI IRAN, ABRARI KATANEH, ELAHDADI SALMANI MAHMOUD, LASKARBOLOUKI TAGHI
 
* FACULTY OF BIOLOGY, DAMGHAN UNIVERSITY, DAMGHAN, IRAN
 
Abstract: 

Introduction: Excessive olivo-cerebellar burst-firing occurs during harmaline-induced tremor. We hypothesized that antiglutamatergic agents would suppress harmaline tremor. From this point of view, the aim of the present study was to investigate the effects of riluzole on harmaline-induced tremor in rat.
Methods: Four groups of Wistar rats weighing 80–100 g were injected with harmaline (30 mg/ kg i.p.) for inducing experimental tremors. The rats in group 1 served as control, whereas the animals in groups 2, 3 and 4 were also given riluzole intraperitonealy at doses of 2, 4 and 8 mg/ kg 30 min before and 90 min after harmaline administration. The onset latency, intensity and duration of tremor were recorded.
Results: The results of this study demonstrated that riluzole could significantly increase latency period, and reduce duration and intensity of tremor.
Discussion: It is concluded that pretreatment of riluzole can ameliorate harmaline-induced tremor in rats.

 
Keyword(s): HARMALINE, TREMOR, RILUZOLE, RAT
 
 
References: 
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Click to Cite.
APA: Copy

RAHIMI SHOURMASTI, F., & GOUDARZI, I., & ABRARI, K., & ELAHDADI SALMANI, M., & LASKARBOLOUKI, T. (2014). RILUZOLE AMELIORATES HARMALINE-INDUCED TREMOR IN RAT. BASIC AND CLINICAL NEUROSCIENCE, 5(2), 138-143. https://www.sid.ir/en/journal/ViewPaper.aspx?id=408748



Vancouver: Copy

RAHIMI SHOURMASTI FATEMEH, GOUDARZI IRAN, ABRARI KATANEH, ELAHDADI SALMANI MAHMOUD, LASKARBOLOUKI TAGHI. RILUZOLE AMELIORATES HARMALINE-INDUCED TREMOR IN RAT. BASIC AND CLINICAL NEUROSCIENCE. 2014 [cited 2021May06];5(2):138-143. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408748



IEEE: Copy

RAHIMI SHOURMASTI, F., GOUDARZI, I., ABRARI, K., ELAHDADI SALMANI, M., LASKARBOLOUKI, T., 2014. RILUZOLE AMELIORATES HARMALINE-INDUCED TREMOR IN RAT. BASIC AND CLINICAL NEUROSCIENCE, [online] 5(2), pp.138-143. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408748.



 
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