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Paper Information

Journal:   BASIC AND CLINICAL NEUROSCIENCE   SPRING 2014 , Volume 5 , Number 2; Page(s) 131 To 137.
 
Paper: 

EFFECT OF CHRONIC RESTRAINT STRESS ON HPA AXIS ACTIVITY AND EXPRESSION OF BDNF AND TRKB IN THE HIPPOCAMPUS OF PREGNANT RATS: POSSIBLE CONTRIBUTION IN DEPRESSION DURING PREGNANCY AND POSTPARTUM PERIOD

 
 
Author(s):  MAGHSOUDI NADER*, GHASEMI RASOUL, GHAEMPANAH ZAHRA, ARDEKANI ALI M., NOOSHINFAR ELAHE, TAHZIBI ABBAS
 
* NEUROSCIENCE RESEARCH CENTER, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Introduction: Brain-Derived Neurotrophic Factor (BDNF) and its receptor, TrkB, in the hippocampus are targets for adverse effects of stress paradigms; in addition, BDNF and its receptor play key role in the pathology of brain diseases like depression. In the present study, we evaluated the possible role of hippocampal BDNF in depression during pregnancy, Methods: To achieve the purpose, repeated restrain stress (1 or 3 hours daily for 7 days) during the last week of pregnancy was used and alteration in the gene expression of hippocampal BDNF and TrkB evaluated by semi-quantitative PCR.
Results: The results showed that in stress group the level of ACTH and Corticosterone is increased showing that our model was efficient in inducing psychological stress; we also found that BDNF and TrkB expression are decreased in 3 hours stress group but not in 1 hour stress compared to control group.
Discussion: Our results imply that decrease in BDNF and its receptor could contribute in some adverse effects of stress during pregnancy such as elevation of depressive like behavior.

 
Keyword(s): STRESS, BDNF, DEPRESSION, ACTH, CORTICOSTERONE, SEMI-QUANTITATIVE RT-PCR
 
 
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APA: Copy

MAGHSOUDI, N., & GHASEMI, R., & GHAEMPANAH, Z., & ARDEKANI, A., & NOOSHINFAR, E., & TAHZIBI, A. (2014). EFFECT OF CHRONIC RESTRAINT STRESS ON HPA AXIS ACTIVITY AND EXPRESSION OF BDNF AND TRKB IN THE HIPPOCAMPUS OF PREGNANT RATS: POSSIBLE CONTRIBUTION IN DEPRESSION DURING PREGNANCY AND POSTPARTUM PERIOD. BASIC AND CLINICAL NEUROSCIENCE, 5(2), 131-137. https://www.sid.ir/en/journal/ViewPaper.aspx?id=408738



Vancouver: Copy

MAGHSOUDI NADER, GHASEMI RASOUL, GHAEMPANAH ZAHRA, ARDEKANI ALI M., NOOSHINFAR ELAHE, TAHZIBI ABBAS. EFFECT OF CHRONIC RESTRAINT STRESS ON HPA AXIS ACTIVITY AND EXPRESSION OF BDNF AND TRKB IN THE HIPPOCAMPUS OF PREGNANT RATS: POSSIBLE CONTRIBUTION IN DEPRESSION DURING PREGNANCY AND POSTPARTUM PERIOD. BASIC AND CLINICAL NEUROSCIENCE. 2014 [cited 2021May18];5(2):131-137. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408738



IEEE: Copy

MAGHSOUDI, N., GHASEMI, R., GHAEMPANAH, Z., ARDEKANI, A., NOOSHINFAR, E., TAHZIBI, A., 2014. EFFECT OF CHRONIC RESTRAINT STRESS ON HPA AXIS ACTIVITY AND EXPRESSION OF BDNF AND TRKB IN THE HIPPOCAMPUS OF PREGNANT RATS: POSSIBLE CONTRIBUTION IN DEPRESSION DURING PREGNANCY AND POSTPARTUM PERIOD. BASIC AND CLINICAL NEUROSCIENCE, [online] 5(2), pp.131-137. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408738.



 
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