Paper Information

Journal:   JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS)   APRIL 2014 , Volume 11 , Number 2; Page(s) 423 To 429.
 
Paper: 

SYNTHESIS, CHARACTERIZATION, ANTICANCER ACTIVITY, THERMAL AND ELECTROCHEMICAL STUDIES OF SOME NOVEL URANYL SCHIFF BASE COMPLEXES

 
 
Author(s):  ASADI ZAHRA*, ASADI MOZAFFAR, DEHGHANI FIRUZABADI FAHIMEH, YOUSEFI REZA, JAMSHIDI MEHRNAZ
 
* DEPARTMENT OF CHEMISTRY, COLLEGE OF SCIENCE, SHIRAZ UNIVERSITY, 71454, SHIRAZ, IRAN
 
Abstract: 

Some tetradentate N2O2 Schiff base ligands, such as N,N'-bis(naphtalidene)-1,2-phenylenediamine, N,N'-bis(naphtalidene)-4-methyl-1,2-phenylenediamine, N,N'-bis(naphtalidene)-4-chloro-1,2-phenylenediamine, N,N'-bis(naphtalidene)-4-nitro-1,2-phenylenediamine, N,N'-bis(naphtalidene)-4-carboxyl-1,2-phenylenediamine, and their uranyl complexes were synthesized and characterized by 1H NMR, IR, UV–Vis spectroscopy, TG (thermogravimetry), and elemental analysis (C.H.N.). Thermogravimetric analysis shows that uranyl complexes have very different thermal stabilities. This method is used also to establish that only one solvent molecule is coordinated to the central uranium ion and this solvent molecule does not coordinate strongly and is removed easier than the tetradentate ligand and also trans oxides. The electrochemical properties of the uranyl complexes were investigated by cyclic voltammetry. Electrochemistry of these complexes showed a quasireversible redox reaction without any successive reactions. Also, the kinetic parameters of thermal decomposition were calculated using Coats-Redfern equation. According to Coats-Redfern plots the kinetics of thermal decomposition of the studied complexes is first-order in all stages. Anticancer activity of the uranyl Schiff base complexes against cancer cell lines (Jurkat) was studied and determined by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazoliumbromide) assay.

 
Keyword(s): URANYL COMPLEX, SCHIFF BASE, ANTICANCER ACTIVITY, THERMAL STUDY, ELECTROCHEMISTRY
 
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