Paper Information

Journal:   JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS)   APRIL 2014 , Volume 11 , Number 2; Page(s) 415 To 422.
 
Paper: 

DETERMINATION OF MANGANESE (VII), CHROMIUM (VI) AND NICKEL (II) IN MEDICINAL HERB SAMPLES BY CLOUD-POINT EXTRACTION AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY

 
 
Author(s):  ZOU DEQING, QING YE, LI YINGTANG, LIU MOSHENG, YANG YALING*
 
* FACULTY OF LIFE SCIENCE AND TECHNOLOGY, KUNMING UNIVERSITY OF SCIENCE AND TECHNOLOGY, KUNMING 650500, CHINA
 
Abstract: 

A highly sensitive method for the determination of manganese (VII), chromium (VI) and nickel (II) in medicinal herb samples is proposed. The method is based on analytes reacted with ammonium pyrrolidinedithiocarbamate (APDC) to give hydrophobic chelates (M-APDC), which were separated and enriched by cloud-point extraction (CPE) with non-ionic surfactant Tergitol TMN-6 as extractant. The surfactant-rich phase containing the chelates is determined with a high-performance liquid chromatography system. To achieve the best CPE method, the Box–Behnken design was used to study the concentration of Tergitol TMN-6, equilibrium temperature, equilibrium time as well as their interaction. What followed was the individual research for the pH of the sample solutions and the concentration of APDC. What is more, in the given optimized experimental conditions, calibration plots were found to be linear in the range of 0.0200-0.500 mg/L for Mn (VII) and Cr (VI), meanwhile 0.0500-1.00 mg/L for Ni (II), the linear correlation coefficients were between 0.996 and 0.999, the recoveries ranged from 91.8 to 97.8 % and the relative standard deviations were between 1.09 and 2.30 %(n= 3). The limits of detection were 0.164 mg/L for Mn (VII), 0.562 mg/L for Cr (VI) and 5.12 mg/L for Ni (II), respectively. The proposed method was applied to determine manganese (VII), chromium (VI) and nickel (II) in medicinal herb samples with satisfactory results.

 
Keyword(s): HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY, AMMONIUM PYRROLIDINEDITHIOCARBAMATE, BOX-BEHNKEN DESIGN, CLOUD-POINT EXTRACTION, MEDICINAL HERBS
 
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