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Paper Information

Journal:   ADVANCED PHARMACEUTICAL BULLETIN   2014 , Volume 4 , Number 3; Page(s) 289 To 293.
 
Paper: 

SELENIUM EFFECT ON OXIDATIVE STRESS FACTORS IN SEPTIC RATS

 
 
Author(s):  ZOLALI ELMIRA, HAMISHEHKAR HADI*, MALEKI DIZAJI NASRIN, MAJIDI ZOLBANIN NAIME, GHAVIMI HAMED, KOUHSOLTANI MARYAM, ASGHARIAN PARINA
 
* FACULTY OF PHARMACY, TABRIZ UNIVERSITY OF MEDICAL SCIENCES, TABRIZ, IRAN
 
Abstract: 

Purpose: Severe oxidative stress is an important event that occurs in patients with sepsis. The body has extensive and multiple defense mechanisms against the reactive oxygen species (ROS) produced during inflammation and sepsis. One of these mechanisms includes a group of enzymes that utilize selenium as their cofactor. The purpose of this study is investigating of Selenium effect on oxidative stress factors in animal model of sepsis.
Methods: Sepsis was induced by caecal ligation and puncture (CLP) method.30 Male Wistar rats were divided into following groups: sham group; CLP group; 100
mg/kg Selenium- treated CLP group.12 hours after inducing sepsis animals were killed and lungs were removed. One of the lungs was frozen in liquid nitrogen and kept at -70oC for enzymatic activity analysis and the other was kept in formalin 10% until tissue section preparation performed for histopathological studies.
Results: The Myeloperoxidase (MPO) activity was decreased in Selenium- treated CLP group. Inflammation score of lung tissue was lowered in Selenium- treated CLP group, but it wasn’t statically significant. Level of glutathione peroxidase (GPx) was higher in CLP and Selenium- treated CLP groups.
Conclusion: It seems that Selenium has protective effect on lung inflammation during acute lung injury. Also it may improve some stress oxidative profile during CLP model of sepsis.

 
Keyword(s): SEPSIS, SELENIUM, CLP, OXIDATIVE STRESS
 
 
References: 
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Click to Cite.
APA: Copy

ZOLALI, E., & HAMISHEHKAR, H., & MALEKI DIZAJI, N., & MAJIDI ZOLBANIN, N., & GHAVIMI, H., & KOUHSOLTANI, M., & ASGHARIAN, P. (2014). SELENIUM EFFECT ON OXIDATIVE STRESS FACTORS IN SEPTIC RATS. ADVANCED PHARMACEUTICAL BULLETIN, 4(3), 289-293. https://www.sid.ir/en/journal/ViewPaper.aspx?id=408671



Vancouver: Copy

ZOLALI ELMIRA, HAMISHEHKAR HADI, MALEKI DIZAJI NASRIN, MAJIDI ZOLBANIN NAIME, GHAVIMI HAMED, KOUHSOLTANI MARYAM, ASGHARIAN PARINA. SELENIUM EFFECT ON OXIDATIVE STRESS FACTORS IN SEPTIC RATS. ADVANCED PHARMACEUTICAL BULLETIN. 2014 [cited 2021May10];4(3):289-293. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408671



IEEE: Copy

ZOLALI, E., HAMISHEHKAR, H., MALEKI DIZAJI, N., MAJIDI ZOLBANIN, N., GHAVIMI, H., KOUHSOLTANI, M., ASGHARIAN, P., 2014. SELENIUM EFFECT ON OXIDATIVE STRESS FACTORS IN SEPTIC RATS. ADVANCED PHARMACEUTICAL BULLETIN, [online] 4(3), pp.289-293. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408671.



 
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