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Paper Information

Journal:   JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)   JUNE 2014 , Volume 19 , Number 6; Page(s) 567 To 570.
 
Paper: 

DETECTION OF QUINOLONE-RESISTANCE MUTATIONS OF PARC GENE IN CLINICAL ISOLATES OF ACINETOBACTER BAUMANNII IN IRAN (SHORT COMMUNICATION)

 
 
Author(s):  VAKILI BAHAREH, KHORVASH FARZIN, FAZELI HOSSEIN*, KHALEGHI MOJ
 
* INFECTIOUS DISEASES AND TROPICAL MEDICINE RESEARCH CANTER, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, IRAN
 
Abstract: 

Background: The purpose of this study was to screen of parC gene mutations in clinical isolates of Acinetobacter baumannii from intensive care units (ICUs) of Alzahra Hospital, Isfahan, Iran.
Materials and Methods: Seventy isolates of A. baumannii between March 2011 and June 2012 were studied. Susceptibility test was established by E-test method. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and sequencing was performed for detection of parC gene mutation.
Results: 77.1% of specimens were highly resistant. Mutation at position 80 in parC was observed in 93% of isolates.
Conclusion: High proportion of A. baumannii isolates had a mutation in parC that can play an important role in increased incidence of these isolates.

 
Keyword(s): A. BAUMANNII, MULTIDRUG RESISTANT, PARC GENE
 
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