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Paper Information

Journal:   JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS)   APRIL 2014 , Volume 11 , Number 2; Page(s) 361 To 367.
 
Paper: 

COPPER-DOPED SILICA CUPROUS SULFATE (CDSCS) AS A HIGHLY EFFICIENT HETEROGENEOUS NANO CATALYST FOR SYNTHESIS OF 3,5-DISUBSTITUTED ISOXAZOLES

 
 
Author(s):  SOLTANI RAD M.N.*, BEHROUZ S.*, FAGHIHI M.A.
 
* DEPARTMENT OF CHEMISTRY, SHIRAZ UNIVERSITY OF TECHNOLOGY, 71555-313, SHIRAZ, IRAN
 
Abstract: 

A facile and highly efficient protocol for 1,3-dipolar cycloaddition of in situ generated nitrile oxides with terminal alkynes catalyzed by copper-doped silica cuprous sulfate (CDSCS) as a new and convenient heterogeneous nano catalyst is described. In this protocol, 'click' cycloaddition of various structurally diverse alkynes and imidoyl chlorides in the presence of CDSCS and NaHCO3 in a solution of i-PrOH/H2O (1:1, V/V) furnishes the corresponding 3,5-disubstituted isoxazoles in good to excellent yields at room temperature. CDSCS was approved as a chemically and thermally stable nano catalyst that can be recovered and reused for many consecutive trials without considerable decline in its reactivity.

 
Keyword(s): ALKYNE, CDSCS, 3,5-DISUBSTITUTED ISOXAZOLE, HETEROGENEOUS NANO CATALYST, NITRILE OXIDE
 
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