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Paper Information

Journal:   JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)   JUNE 2014 , Volume 19 , Number 6; Page(s) 525 To 530.
 
Paper: 

MEMANTINE ADD ON TO CITALOPRAM IN ELDERLY PATIENTS WITH DEPRESSION: A DOUBLE-BLIND PLACEBO-CONTROLLED STUDY

 
 
Author(s):  OMRANIFARD VICTORIA, SHIRZADI ELHAM, SAMANDARI SAEID, AFSHAR HAMID*, MARACY MOHAMMAD REZA
 
* PSYCHOSOMATIC RESEARCH CENTER, DEPARTMENT OF PSYCHIATRY, FACULTY OF MEDICINE, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, IRAN
 
Abstract: 

Background: Proper management of depression in elderly population would improve the outcome of the disease and reduce its related disability and mortality. Use of memantine with minimal side effects and drug interaction seems reasonable in the elderly but its antidepressant activity is controversial. The aim of the current research is to investigate the effects of add-on memantine during citalopram therapy in elderly patients with depression, in Isfahan.
Materials and Methods: In this double-blind, placebo controlled trial study; elderly patients aged more than 60 years who were recently diagnosed with depression, were enrolled. The selected patients were randomly split into two groups, viz. intervention and placebo groups. The intervention was memantine (20 mg daily) or identical placebo plus citalopram for 8 weeks. The severity of depression and quality of life was evaluated using Geriatric Depression Scale (GDS-15), Hamilton Rating Scale for depression (HRSD) and World Health Organization Quality of Life WHOQOL-BREF respectively. The mentioned scores were evaluated at baseline, 4 weeks and 8 weeks, after initiating the trial in two studied groups and compared with each other.
Results: 28 and 29 patients were studied in the intervention and placebo groups, respectively. Score of GDS-15, HRSD and WHO-QOL-BREF scales at baseline, 4 weeks and 8 weeks, after initiating trial did not change significantly after use of memantine (P>0.05). There was no significant difference in mean +/- SD of GDS-15, HRSD and WHO-QOL-BREF scales among intervention and placebo groups (P>0.05).
Conclusion: The outcome of this clinical trial did not support the antidepressant effect of add-on memantine in elderly patients with depression receiving citalopram. It is recommended to design further studies considering the limitations of the current study mentioned herein and the eff ect of memantine with other anti-depressant agents.

 
Keyword(s): DEPRESSION, GERIATRIC, MEMANTINE, QUALITY OF LIFE
 
 
References: 
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Click to Cite.
APA: Copy

OMRANIFARD, V., & SHIRZADI, E., & SAMANDARI, S., & AFSHAR, H., & MARACY, M. (2014). MEMANTINE ADD ON TO CITALOPRAM IN ELDERLY PATIENTS WITH DEPRESSION: A DOUBLE-BLIND PLACEBO-CONTROLLED STUDY. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 19(6), 525-530. https://www.sid.ir/en/journal/ViewPaper.aspx?id=408609



Vancouver: Copy

OMRANIFARD VICTORIA, SHIRZADI ELHAM, SAMANDARI SAEID, AFSHAR HAMID, MARACY MOHAMMAD REZA. MEMANTINE ADD ON TO CITALOPRAM IN ELDERLY PATIENTS WITH DEPRESSION: A DOUBLE-BLIND PLACEBO-CONTROLLED STUDY. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS). 2014 [cited 2021May07];19(6):525-530. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408609



IEEE: Copy

OMRANIFARD, V., SHIRZADI, E., SAMANDARI, S., AFSHAR, H., MARACY, M., 2014. MEMANTINE ADD ON TO CITALOPRAM IN ELDERLY PATIENTS WITH DEPRESSION: A DOUBLE-BLIND PLACEBO-CONTROLLED STUDY. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), [online] 19(6), pp.525-530. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408609.



 
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