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Paper Information

Journal:   JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)   JUNE 2014 , Volume 19 , Number 6; Page(s) 502 To 508.
 
Paper: 

COMPARING LOW-DOSE INTRAVENOUS KETAMINE-MIDAZOLAM WITH INTRAVENOUS MORPHINE WITH RESPECT TO PAIN CONTROL IN PATIENTS WITH CLOSED LIMB FRACTURE

 
 
Author(s):  AHMADI OMID, NASR ISFAHANI MEHDI*, FEIZI AWAT
 
* DEPARTMENT OF EMERGENCY MEDICINE, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, IRAN
 
Abstract: 

Background: We assessed the effects of low-dose IV ketamine-midazolam versus morphine on pain control in patients with closed limb fracture(s); and also compared the incidence of adverse events (cardio-pulmonary) between two groups.
Materials and Methods: Th is prospective, single-blind, non-inferiority trial randomized consecutive emergency department (ED) patients aged 18-60 years to two groups: Receiving 300-500 mcg/kg ketamine plus 0.03 mg/kg midazolam, or 0.05-0.1 mg/kg morphine. Visual analogue score (VAS) and adverse events were verified during an interval of 30 minutes.
Results: Two hundred and thirty-six patients were selected, among whom 207 were males (87.3%). The average age was 29
±2, (range, 18-60 years). The VAS score at T30 (i.e., 30 minutes after initial analgesic dose) was significantly decreased compared with VAS score at T0, in both groups. No statistically significant difference, however, was observed between the two groups (-6.1±1.1 versus -6.2±1.0; P=0.16). With regard to systolic blood pressure and respiratory rate, however, a meaningful difference was noted between the two groups (1.5±6.4 versus -2.1±6.6; P=0.000 for SBP, and -0.2±1.1 versus -1.1±6.1; P=0.048 for RR).
Conclusion: “Low-dose” intravenous ketamine plus midazolam has the same analgesic effects as morphine on pain control in trauma patients with closed limb fracture(s), in addition to less respiratory adverse events.

 
Keyword(s): CLOSED LIMB FRACTURE, KETAMINE, MIDAZOLAM, MORPHINE
 
 
References: 
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Click to Cite.
APA: Copy

AHMADI, O., & NASR ISFAHANI, M., & FEIZI, A. (2014). COMPARING LOW-DOSE INTRAVENOUS KETAMINE-MIDAZOLAM WITH INTRAVENOUS MORPHINE WITH RESPECT TO PAIN CONTROL IN PATIENTS WITH CLOSED LIMB FRACTURE. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 19(6), 502-508. https://www.sid.ir/en/journal/ViewPaper.aspx?id=408589



Vancouver: Copy

AHMADI OMID, NASR ISFAHANI MEHDI, FEIZI AWAT. COMPARING LOW-DOSE INTRAVENOUS KETAMINE-MIDAZOLAM WITH INTRAVENOUS MORPHINE WITH RESPECT TO PAIN CONTROL IN PATIENTS WITH CLOSED LIMB FRACTURE. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS). 2014 [cited 2021May12];19(6):502-508. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408589



IEEE: Copy

AHMADI, O., NASR ISFAHANI, M., FEIZI, A., 2014. COMPARING LOW-DOSE INTRAVENOUS KETAMINE-MIDAZOLAM WITH INTRAVENOUS MORPHINE WITH RESPECT TO PAIN CONTROL IN PATIENTS WITH CLOSED LIMB FRACTURE. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), [online] 19(6), pp.502-508. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408589.



 
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