Paper Information

Journal:   ADVANCED PHARMACEUTICAL BULLETIN   2014 , Volume 4 , Number 2; Page(s) 179 To 183.
 
Paper: 

ANTINOCICEPTIVE EFFECT OF SOME BIURET DERIVATIVES ON FORMALIN TEST IN MICE

 
 
Author(s):  ADIBPOUR NEDA*, POORNAJJARI ALI, KHODAYAR MOHAMMAD JAVAD, REZAEE SAEED
 
* DEPARTMENT OF MEDICINAL CHEMISTRY, SCHOOL OF PHARMACY, ZANJAN UNIVERSITY OF MEDICAL SCIENCES, ZANJAN, IRAN
 
Abstract: 

Purpose: The current study was designed to investigate the antinociceptive effects of several biuret derivatives with N, N’-diphenyl, N-phenyl-N’-alkylphenyl, N, N’-bis alkylphenyl, 2-methylquinoline-4-yl, benzo [d] thiazol-2-ylthio and (1-phenyl-1H-tetrazol-5-yl) thio substituents on the formalin-evoked pain in mice.
Methods: Antinociceptive activity of the nine biurets derivatives were assessed at different doses in mice using formalin test and the results were compared with those of indomethacin (20 mg/kg) and vehicle of the compounds. Area under the pain score curve against time (AUEC) up to 60 minutes was used as the measure of pain behavior.
Results: A rather good analgesic effect was seen for most of the tested biuret derivatives. Significant reduction in median AUEC0-5 minutes was observed at the doses of 50 and 25 mg/kg for biurets with either benzyl and 2-methylquinoline-4-yl (C8) or phenylethyl and benzo [d] thiazol-2-ylthio (C9) moieties, respectively (p-value<0.0044). Antinociceptive activities of compound C7 (with bis phenylropyl substituent), C8 and C9 during the late phase of formaldehyde-induced pain were comparable to that of indomethacin.
Conclusion: Unlike indomethacin, the tested biuret compounds are able to induce antinociception in both phases of formalin test and could be considered comparable to indomethacin at the selected doses.

 
Keyword(s): BIURET DERIVATIVES, ANTINOCICEPTIVE EFFECT, FORMALIN TEST, MICE
 
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