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Paper Information

Journal:   ADVANCED PHARMACEUTICAL BULLETIN   2014 , Volume 4 , Number 2; Page(s) 161 To 165.
 
Paper: 

SIMULTANEOUS DETERMINATION OF LORATADINE, DESLORATADINE AND CETIRIZINE BY CAPILLARY ZONE ELECTROPHORESIS

 
 
Author(s):  HANCU GABRIEL*, CAMPIAN CAMELIA, RUSU AURA, MIRCIA ELEONORA, KELEMEN HAJNAL
 
* FACULTY OF PHARMACY, UNIVERSITY OF MEDICINE AND PHARMACY TARGU MURES, GHMARINESCU 38, 540000 TARGU MURES, ROMANIA
 
Abstract: 

Purpose: The aim of the study was the development of a simple and rapid analytical procedure for the determination of the most frequently used antihistamine derivatives.
Methods: A capillary zone electrophoretic method was developed for the simultaneous separation of loratadine, desloratadine and cetirizine. Efforts were focused primarly on the optimisation of the experimental parameters: buffer composition and concentration, buffer pH, applied voltage, temperature, injection pressure and time.
Results: The optimised parameters for the separation were: 25 mM buffer electrolyte, buffer pH 2.5, voltage+25 kV, temperature 25 oC, injection pressure 50 mbar, injection time 3 seconds, capillary 48 cm (effective length 40 cm) x 50
mm, detection at 240 nm. Under these conditions, the analysis time was below 5 minutes, the order of migration being: desloratadine, cetirizine and loratadine. The developed method was validated in terms of linearity, limits of detection and quantification, intra- and inter-day precision, selectivity and robustness.
Conclusion: Capillary zone electrophoresis proved to be a suitable method for the simulatneous determination of the three studied antihistamine derivatives.

 
Keyword(s): ANTIHISTAMINES, LORATADINE, DESLORATADINE, CETIRIZINE, CAPILLARY ELECTROPHORESIS, SEPARATION
 
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