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Paper Information

Journal:   ADVANCED PHARMACEUTICAL BULLETIN   2014 , Volume 4 , Number 2; Page(s) 131 To 138.
 
Paper: 

THE EFFECT OF ADENOSINE A2A AND AB ANTAGONISTS ON TRACHEAL RESPONSIVENESS, SERUM LEVELS OF CYTOKINES AND LUNG INFLAMMATION IN GUINEA PIG MODEL OF ASTHMA

 
 
Author(s):  PEJMAN LALEH, OMRANI HASAN, MIRZAMOHAMMADI ZAHRA, SHAHBAZFAR AMIR ALI, KHALILI MAJID, KEYHANMANESH RANA*
 
* TUBERCULOSIS AND LUNG RESEARCH CENTER, TABRIZ UNIVERSITY OF MEDICAL SCIENCES, TABRIZ, IRAN
 
Abstract: 

Purpose: Nowadays adenosine is specified as an important factor in the pathophysiology of asthma. For determining the effect of different A2 receptors, in this investigation the effect of single dose of selective adenosine A2A and A2B antagonists (ZM241385 and MRS1706) on different inflammatory parameters; tracheal responsiveness to methacholine and ovalbumin, total and differential cell count in bronchoalveolar lavage (BAL), blood levels of IL-4 and IFN-g and lung pathology of guinea pig model of asthma were assessed.
Methods: All mentioned parameters were evaluated in two sensitized groups of guinea pigs pretreated with A2A and A2B antagonists (S+Anta A2A, S+Anta A2B) compared with sensitized (S) and control (C) groups.
Results: The tracheal responsiveness to methacholine and OA, total cell and eosinophil and basophil count in BAL, blood IL-4 level and pathological changes in pre-treated group with MRS1706 (S+Anta A2B) was significantly lower than those of sensitized group (p<0.01 to p<0.05). In pretreated group with Anta A2A (S+Anta A2A), all the above changes were reversed.
Conclusion: These results showed a preventive effect of A2B antagonist (MRS1706) on tracheal responsiveness to methacholine and OA, total and differential cell count in bronchoalveolar lavage, blood cytokines and pathological changes. Administration of ZM241385, selective A2A antagonist, deteriorated the induction effect of ovalbumin.

 
Keyword(s): ZM241385, MRS1706, ADENOSINE A2A AND A2B RECEPTOR, ASTHMA, GUINEA PIG
 
References: 
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