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Paper Information

Journal:   ADVANCED PHARMACEUTICAL BULLETIN   2014 , Volume 4 , Number 2; Page(s) 121 To 130.
 
Paper: 

DESIGN EXPERT ASSISTED FORMULATION OF TOPICAL BIOADHESIVE GEL OF SERTACONAZOLE NITRATE

 
 
Author(s):  PANDE VISHAL*, PATEL SAMIR, PATIL VIJAY, SONAWANE RAJU
 
* H.R. PATEL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH, SHIRPUR, DHULE, MAHARASHTRA, 425405 INDIA
 
Abstract: 

Purpose: The objective of this work was to develop a bioadhesive topical gel of sertaconazole nitrate with the help of response-surface approach.
Methods: Experiments were performed according to a 3-level factorial design to evaluate the effects of two independent variables [amount of Carbapol 934=X1) and Sodium carboxymethylcellulose (NaCMC) =X2)] on the bioadhesive character of gel, rheological property of gel (consistency index), and in-vitro drug release. The best model was selected to fit the data.
Results: Mathematical equation was generated by Design Expert
? software for the model which assists in determining the effect of independent variables. Response surface plots were also generated by the software for analyzing effect of the independent variables on the response. The effect of formulation variables on the product characteristics can be easily predicted and precisely interpreted by using a 3-level factorial design and generated quadratic mathematical equations.
Conclusion: On the basis of product characteristics viscosity, bioadhesiveness, permeation study, in-vitro release, in-vivo studies, TPA and spreadability it can be concluded that the best batch of topical bioadhesive gel of Sertaconazole nitrate would be with 1% Carbopol 934 and 1% NaCMC.

 
Keyword(s): TOPICAL BIOADHESIVE GEL, SERTACONAZOLE NITRATE, THREE-LEVEL FACTORIAL DESIGN, CARBAPOL, NACMC
 
 
References: 
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APA: Copy

PANDE, V., & PATEL, S., & PATIL, V., & SONAWANE, R. (2014). DESIGN EXPERT ASSISTED FORMULATION OF TOPICAL BIOADHESIVE GEL OF SERTACONAZOLE NITRATE. ADVANCED PHARMACEUTICAL BULLETIN, 4(2), 121-130. https://www.sid.ir/en/journal/ViewPaper.aspx?id=408454



Vancouver: Copy

PANDE VISHAL, PATEL SAMIR, PATIL VIJAY, SONAWANE RAJU. DESIGN EXPERT ASSISTED FORMULATION OF TOPICAL BIOADHESIVE GEL OF SERTACONAZOLE NITRATE. ADVANCED PHARMACEUTICAL BULLETIN. 2014 [cited 2021May18];4(2):121-130. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408454



IEEE: Copy

PANDE, V., PATEL, S., PATIL, V., SONAWANE, R., 2014. DESIGN EXPERT ASSISTED FORMULATION OF TOPICAL BIOADHESIVE GEL OF SERTACONAZOLE NITRATE. ADVANCED PHARMACEUTICAL BULLETIN, [online] 4(2), pp.121-130. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408454.



 
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