Paper Information

Journal:   JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)   MAY 2014 , Volume 7 , Number 5; Page(s) 0 To 0.
 
Paper:  ALLELIC FORMS OF MEROZOITE SURFACE PROTEIN-3 IN PLASMODIUM FALCIPARUM ISOLATES FROM SOUTHEAST OF IRAN
 
Author(s):  EBRAHIMZADEH ADEL*, MOHAMMADI SAEED, JAMSHIDI ALI
 
* DEPARTMENT OF PARASITOLOGY AND MYCOLOGY, ZAHEDAN UNIVERSITY OF MEDICAL SCIENCES, ZAHEDAN, IR IRAN
 
Abstract: 

Background: Genetic diversity has provided Plasmodium falciparum with the potential capacity of avoiding the immune response, and possibly supported the natural selection of drug or vaccine-resistant parasites. Merozoite surface protein-3 (MSP-3) has been used to develop vaccines and investigate the genetic diversity regarding P. falciparum malaria in Iran.
Objectives: The main goal of this study was to analyze the polymorphic antigen MSP-3 genes across southeast of Iran among four different districts, to identify the differences in the allele frequency and genetic diversity.
Materials and Methods: Nested polymerase chain reaction amplification was used to determine polymorphisms of N-terminal region of the MSP-3 gene. A total of 85 microscopically positive P. falciparum infected individuals from southeast of Iran were included in this study.
Results: Of the 85 confirmed P. falciparum samples obtained from four different districts, 72 were successfully scored for MSP-3.The MSP-3 allele classes (K1 and 3D7 types) showed comparable prevalence in all districts. Overall frequencies of K1 and 3D7 allele classes were 94.5 % for both.
Conclusions: Since no study has yet looked at the extent of P. falciparum MSP-3 in this geographic region, these data can be helpful to support development of a vaccine based on MSP-3 against malaria. There should be a comparative analysis in different seasonal peaks to indicate the allelic polymorphism of MSP-3 over a period.

 
Keyword(s): PLASMODIUM FALCIPARUM, MEROZOITE SURFACE PROTEIN 3, PLASMODIUM, GENETIC VARIATION, IRAN
 
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