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Paper Information

Journal:   JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)   JULY 2014 , Volume 7 , Number 7; Page(s) 0 To 0.
 
Paper: 

QUINOLONE SUSCEPTIBILITY AND DETECTION OF QNR AND AAC (6’)- IB-CR GENES IN COMMUNITY ISOLATES OF KLEBSIELLA PNEUMONIA

 
 
Author(s):  SEYEDPOUR SEYED MOHSEN, EFTEKHAR FERESHTEH*
 
* DEPARTMENT OF MICROBIOLOGY, FACULTY OF BIOLOGICAL SCIENCES, SHAHID BEHESHTI UNIVERSITY, G.C., TEHRAN, IR IRAN
 
Abstract: 

Background: Plasmid-mediated quinolone resistance genes (PMQR) have been shown to play not only an important role in quinolone resistance, but also resistance to other antibiotics, particularly b-lactams and aminoglycosides. These genes are mainly associated with clinical isolates of Enterobacteriaceae. However, detection of PMQR genes in the community isolates can increase the dissemination rate of resistance determinants among bacteria.
Objectives: This study aimed to investigate quinolone resistance and distribution of qnr and aac (6’)- Ib-cr genes among the community isolates of Klebsiella pneumoniae.
Materials and Methods: Fifty-two K. pneumoniae isolates were collected from the Central Laboratory in Karaj between July 2010 and January 2011. Antibacterial susceptibility was determined by the disc diffusion method. Quinolone and/or cephalosporin-resistant isolates were screened for the presence of qnr A, qnr B, qnr S and aac (6’)- Ib-cr genes by polymerase chain reaction (PCR).
Results: Of the 52 K. pneumoniae isolates, 23 were resistant to cephalosporins and/or quinolones. Overall, 7 out of the 23 resistant isolates harbored qnr and/or aac (6’)- Ib-cr genes (30.4%). Among these, 5 isolates were resistant to both classes of antibiotics of which; 3 carried the aac (6’) - Ib-cr gene, one had the qnr S, and one harbored both aac (6’)- Ib-cr and qnr B genes. None of the isolates contained qnr A. Two isolates were sensitive to quinolones and resistant to cephalosporins of which; one had qnr S and the other carried the aac (6’)- Ib-cr gene.
Conclusions: Our study showed that 30.4% of the quinolone and/or cephalosporin resistant community isolates of K. pneumoniae carried PMQR genes. These results confirm that community isolates can be an important source for spreading antibiotic resistance determinants among Gram negative pathogens. This is the first report from Iran on detection of PMQR in the community isolates of K. pneumoniae.

 
Keyword(s): KLEBSIELLA PNEUMONIA, QUINOLONE RESISTANCE, PMQR, QNR, AAC (6’)-IB-CR QNR GENES
 
 
References: 
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Click to Cite.
APA: Copy

SEYEDPOUR, S., & EFTEKHAR, F. (2014). QUINOLONE SUSCEPTIBILITY AND DETECTION OF QNR AND AAC (6’)- IB-CR GENES IN COMMUNITY ISOLATES OF KLEBSIELLA PNEUMONIA. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 7(7), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=408429



Vancouver: Copy

SEYEDPOUR SEYED MOHSEN, EFTEKHAR FERESHTEH. QUINOLONE SUSCEPTIBILITY AND DETECTION OF QNR AND AAC (6’)- IB-CR GENES IN COMMUNITY ISOLATES OF KLEBSIELLA PNEUMONIA. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM). 2014 [cited 2021May12];7(7):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408429



IEEE: Copy

SEYEDPOUR, S., EFTEKHAR, F., 2014. QUINOLONE SUSCEPTIBILITY AND DETECTION OF QNR AND AAC (6’)- IB-CR GENES IN COMMUNITY ISOLATES OF KLEBSIELLA PNEUMONIA. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), [online] 7(7), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408429.



 
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