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Paper Information

Journal:   INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE   2014 , Volume 5 , Number 7; Page(s) 835 To 840.
 
Paper: 

BENEFICIAL ROLE OF ANTIOXIDANTS ON CLINICAL OUTCOMES AND ERYTHROCYTE ANTIOXIDANT PARAMETERS IN RHEUMATOID ARTHRITIS PATIENTS

 
 
Author(s):  JALILI MAHSA, KOLAHI SOUSAN*, AREF HOSSEINI SEYED RAFI, EBRAHIMI MAMEGANI MEHRANGIZ, HEKMATDOOST AZITA
 
* RHEUMATOLOGY RESEARCH TEAM, IMAM REZA HOSPITAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, TABRIZ, IRAN
 
Abstract: 

Background: This study aims to investigate the effect of antioxidants supplement on clinical outcomes and antioxidant parameters in rheumatoid arthritis (RA).
Methods: The pre-post study was conducted on 40 female patients with RA in 12 weeks that taken daily one "Selenplus" capsule contained 50 ?g selenium, 8 mg zinc, 400 ?g vitamin A, 125 mg vitamin C, and 40 mg vitamin E. About 5 mL venous blood sample was taken from all participants and disease activity score (DAS) was determined by DAS-28 formula and high-sensitive C-reactive protein (hs-CRP). Glutathione peroxidase (GPX) and superoxide dismutase (SOD) were measured by spectrophotometric kit and catalase (CAT) was measured by Abei method. Total antioxidant capacity (TAC) was determined by spectrophotometric kit. Distribution of the variables was assessed using histogram with normal curve as well as Kolmogorov-Smirnov test and data were analyzed with paired t -test for differences between pre-post data using SPSS software version 13.5.
Results: Out of 40 patients, 39 completed the study. DAS-28 score and hs-CRP have changed (P<0.01 for both), while the number of swollen and painful joints did not reduce significantly. TAC, GPX, SOD, and CAT increased significantly (P<0.01 for all variables).
Conclusions: Our findings showed that antioxidants may improve disease activity significantly, but it did not affect the number of painful and swollen joints and increased erythrocyte antioxidant levels. Antioxidants may be useful for controlling of clinical outcomes and oxidative stress in RA.

 
Keyword(s): ANTIOXIDANTS, DIETARY SUPPLEMENTS, NUTRITION, OXIDATIVE STRESS, RHEUMATOID ARTHRITIS
 
 
References: 
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Click to Cite.
APA: Copy

JALILI, M., & KOLAHI, S., & AREF HOSSEINI, S., & EBRAHIMI MAMEGANI, M., & HEKMATDOOST, A. (2014). BENEFICIAL ROLE OF ANTIOXIDANTS ON CLINICAL OUTCOMES AND ERYTHROCYTE ANTIOXIDANT PARAMETERS IN RHEUMATOID ARTHRITIS PATIENTS. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, 5(7), 835-840. https://www.sid.ir/en/journal/ViewPaper.aspx?id=408410



Vancouver: Copy

JALILI MAHSA, KOLAHI SOUSAN, AREF HOSSEINI SEYED RAFI, EBRAHIMI MAMEGANI MEHRANGIZ, HEKMATDOOST AZITA. BENEFICIAL ROLE OF ANTIOXIDANTS ON CLINICAL OUTCOMES AND ERYTHROCYTE ANTIOXIDANT PARAMETERS IN RHEUMATOID ARTHRITIS PATIENTS. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE. 2014 [cited 2021May10];5(7):835-840. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408410



IEEE: Copy

JALILI, M., KOLAHI, S., AREF HOSSEINI, S., EBRAHIMI MAMEGANI, M., HEKMATDOOST, A., 2014. BENEFICIAL ROLE OF ANTIOXIDANTS ON CLINICAL OUTCOMES AND ERYTHROCYTE ANTIOXIDANT PARAMETERS IN RHEUMATOID ARTHRITIS PATIENTS. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, [online] 5(7), pp.835-840. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408410.



 
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