Paper Information

Journal:   INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE   2014 , Volume 5 , Number 4; Page(s) 430 To 438.
 
Paper: 

ASSOCIATION OF HUMAN PAPILLOMA VIRUS 16 INFECTION AND P53 POLYMORPHISM AMONG TOBACCO USING ORAL LEUKOPLAKIA PATIENTS: A CLINICOPATHOLOGIC AND GENOTYPIC STUDY

 
 
Author(s):  SIKKA SEEMA*, SIKKA PRANAV
 
* DEPARTMENT OF ORAL AND MAXILLOFACIAL PATHOLOGY, SUDHA RASTOGI DENTAL COLLEGE, FARIDABAD, HARYANA, INDIA
 
Abstract: 

Background: Human papillomavirus (HPV) and p53 alterations are speculated to play a role in carcinogenesis. This study was carried out to find out the association of HPV and p53 with precancerous lesions of the oral cavity such as leukoplakia: The objective of this study was to find the association among human papilloma virus (HPV) 16 infections and p53 polymorphism in tobacco using the oral leukoplakia patients.
Methods: A total of 91 oral leukoplakia patients and 100 controls were randomly selected from the out-patient department of a tertiary care dental hospital of North-east India. Blood samples were drawn incisional biopsy was performed from the lesion proper and the tissue was processed for histopathological grading. Cytological smears were taken from the lesional site of leukoplakia patients and buccal mucosa of controls. The rate of HPV infection and p53 polymorphism was detected with the help of polymerase chain reaction, gel electrophoresis and deoxyribonucleic acid sequencing.
Results: The rate of HPV 16 infection was found significantly high in the oral leukoplakia patients. No particular p53 genotype at exon 4 of codon 72 was found to be associated with oral leukoplakia, but "C" allele (proline) at exon 4 of codon 72 was significantly raised in these patients.
Conclusions: Oral leukoplakia, a well-known pre-cancerous lesion, has been shown to be associated with tobacco, but certain other factors like HPV infection and p53 polymorphism may play an important role in its development.

 
Keyword(s): HUMAN PAPILLOMA VIRUS, ORAL LEUKOPLAKIA, P53 POLYMORPHISM, TOBACCO
 
References: 
  • ندارد
 
  pdf-File tarjomyar Yearly Visit 74
 
Latest on Blog
Enter SID Blog