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Paper Information

Journal:   JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)   MAY 2014 , Volume 7 , Number 5; Page(s) 0 To 0.
 
Paper: 

THE RISE OF STAPHYLOCOCCAL SUPER ANTIGENS IN PSORIATIC PATIENTS: A CASE-CONTROL STUDY

 
 
Author(s):  ATEFI NAJMOSADAT, NOORBAKHSH SAMILEH*, GHAVIDEL DARESTANI SAHAR, TABATABAEI AZARDOKHT, REZAEI MOHAMMAD REZA
 
* RESEARCH CENTER OF PEDIATRIC INFECTIOUS DISEASES, IRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IR IRAN
 
Abstract: 

Background: Staphylococcus aureus, the major virulence factor of hospital and community acquired infections, secretes numerous exotoxins (super antigens), which may affect immunological and inflammatory status in psoriatic skin lesion.
Objectives: This study is designed to compare the S. aureus super antigens level in sera of psoriatic patients with normal cases (nevus).
Patients and Methods: A case control study was performed in dermatology ward of Rasoul Hospital in Tehran, IR Iran (2008 - 2010). Staphylococcal super antigens (Entrotoxin A, B, D and TSST1) were measured in serum of 41 psoriatic patients and 28 normal persons (Nevus) by ELISA. Chi square values (CI 95%, P value<0.05) were calculated for all categorical variables.
Results: In this study 63.4% (26) of cases were male, 36.6% (15) were female. Age ranged from 4 months to 64 years old, with a mean age of 33.7±15.4 years. Type of skin disease in cases: 20% (8) were inflicted by the Gutate form of the disease; 59% (23) with chronic plaque psoriasis (CPP), 7.7% (3) with erythrodermic and 12.8% (5) had other types of the disease (plaque, pustular, inverse). TSST (toxic shock syndrome toxin) was detected in 47% (20.41) of cases and in 6% (1.28) of the controls with a significant difference. (P value=0.000) Entrotoxins (A, B, D) were detected in the sera of 48.8% (21.41) of cases; and only 6 % (1.21) of controls, showed significant differences (P value=0.000) positive TSST was more common in spring, and correlates with CPP type of psoriasis, but not related to patient’s gender and age.
Conclusions: In this study, S. aureus were 25 times more in psoriatic patients. Super antigens should be first detected in the serum samples; if negative, the skin lesions should be examined by PCR especially in chronic types of disease. Adding the antibiotics against S. aureus to other conventional treatments might be helpful. It has a more important and significant role in children with acuteinfection.

 
Keyword(s): PSORIASIS, ENTEROTOXIN F, STAPHYLOCOCCAL, STAPHYLOCOCCAL ENTEROTOXIN (A, B, D)
 
 
References: 
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Click to Cite.
APA: Copy

ATEFI, N., & NOORBAKHSH, S., & GHAVIDEL DARESTANI, S., & TABATABAEI, A., & REZAEI, M. (2014). THE RISE OF STAPHYLOCOCCAL SUPER ANTIGENS IN PSORIATIC PATIENTS: A CASE-CONTROL STUDY. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 7(5), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=408404



Vancouver: Copy

ATEFI NAJMOSADAT, NOORBAKHSH SAMILEH, GHAVIDEL DARESTANI SAHAR, TABATABAEI AZARDOKHT, REZAEI MOHAMMAD REZA. THE RISE OF STAPHYLOCOCCAL SUPER ANTIGENS IN PSORIATIC PATIENTS: A CASE-CONTROL STUDY. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM). 2014 [cited 2021May14];7(5):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408404



IEEE: Copy

ATEFI, N., NOORBAKHSH, S., GHAVIDEL DARESTANI, S., TABATABAEI, A., REZAEI, M., 2014. THE RISE OF STAPHYLOCOCCAL SUPER ANTIGENS IN PSORIATIC PATIENTS: A CASE-CONTROL STUDY. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), [online] 7(5), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408404.



 
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