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Paper Information

Journal:   JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS)   JUNE 2014 , Volume 11 , Number 3; Page(s) 607 To 613.
 
Paper: 

SYNTHESIS, ANTIBACTERIAL AND ANTIOXIDANT ACTIVITY OF NOVEL 2, 3-DIHYDROQUINAZOLIN-4 (1H) -ONE DERIVATIVES OF DEHYDROABIETYLAMINE DITERPENE

 
 
Author(s):  SALEHI PEYMAN*, AYYARI MAHDI, BARARJANIAN MORTEZA, NEJAD EBRAHIMI SAMAD, ALIAHMADI ATOUSA
 
* DEPARTMENT OF PHYTOCHEMISTRY, MEDICINAL PLANTS AND DRUGS RESEARCH INSTITUTE, SHAHID BEHESHTI UNIVERSITY, G. C., EVIN, 1983963113, TEHRAN, IRAN
 
Abstract: 

A series of novel 2,3-dihydroquinazolin-4(1H)-ones was synthesized by a three-component reaction between dehydroabietylamine (DHA) diterpene, isatoic anhydride and different aromatic aldehydes in the presence of a catalytic amount of p-toluenesulfonic acid (13 mol%). Diastereomeric products were separated by preparative thin-layer chromatography and their structures were characterized by1H and 13C NMR, HMQC, IR and HR-ESI-MS. Antioxidant activities of the synthesized compounds were assessed by two different methods including DPPH and ?-carotene-linoleic acid bleaching assays. Antibacterial activities of the compounds were also evaluated against two Gram-positive and one Gram-negative bacterial strains and in the case of Bacillus cereus a considerable inhibitory effect (MIC 4–16 mg/ml) was observed.

 
Keyword(s): 2,3-DIHYDROQUINAZOLIN-4(1H)-ONES, DEHYDROABIETYLAMINE, DIASTEREOMERS, MULTI-COMPONENT REACTION
 
 
References: 
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Click to Cite.
APA: Copy

SALEHI, P., & AYYARI, M., & BARARJANIAN, M., & NEJAD EBRAHIMI, S., & ALIAHMADI, A. (2014). SYNTHESIS, ANTIBACTERIAL AND ANTIOXIDANT ACTIVITY OF NOVEL 2, 3-DIHYDROQUINAZOLIN-4 (1H) -ONE DERIVATIVES OF DEHYDROABIETYLAMINE DITERPENE. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), 11(3), 607-613. https://www.sid.ir/en/journal/ViewPaper.aspx?id=408389



Vancouver: Copy

SALEHI PEYMAN, AYYARI MAHDI, BARARJANIAN MORTEZA, NEJAD EBRAHIMI SAMAD, ALIAHMADI ATOUSA. SYNTHESIS, ANTIBACTERIAL AND ANTIOXIDANT ACTIVITY OF NOVEL 2, 3-DIHYDROQUINAZOLIN-4 (1H) -ONE DERIVATIVES OF DEHYDROABIETYLAMINE DITERPENE. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS). 2014 [cited 2021May10];11(3):607-613. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408389



IEEE: Copy

SALEHI, P., AYYARI, M., BARARJANIAN, M., NEJAD EBRAHIMI, S., ALIAHMADI, A., 2014. SYNTHESIS, ANTIBACTERIAL AND ANTIOXIDANT ACTIVITY OF NOVEL 2, 3-DIHYDROQUINAZOLIN-4 (1H) -ONE DERIVATIVES OF DEHYDROABIETYLAMINE DITERPENE. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), [online] 11(3), pp.607-613. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408389.



 
 
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