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Paper Information

Journal:   INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE   2014 , Volume 5 , Number 8; Page(s) 999 To 1004.
 
Paper: 

THE EFFECT OF VITAMIN C ON ENDOTHELIAL FUNCTION OF CHILDREN WITH TYPE 1 DIABETES: AN EXPERIMENTAL STUDY

 
 
Author(s):  SABRI MOHAMMAD REZA, NAJAFI TAVANA ESFANDIAR*, AHMADI ALIREZA, HASHEMIPOUR MAHIN
 
* DEPARTMENT OF PEDIATRICS, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, IRAN
 
Abstract: 

Background: Considering the importance of improvement of endothelial function in patients with type 1 diabetes mellitus (DM) and to prevent its related micro- and macro-vascular complications; in this study, the effect of vitamin C administration on improving endothelial function of children with type 1 diabetes was investigated.
Methods: In this analytic-experimental study, children with type 1 DM aged 6-18 years and a group of healthy children enrolled. Vitamin C (250 mg/daily) administrated for the two studied groups for 1-month. Endothelial function evaluated by flow-mediated dilatation (FMD) and intima-media thickness (IMT) measurement using vascular Doppler ultrasonography, before and after trial.
Results: In this study, 18 patients with type 1 diabetes (DM) and 19 normal children as the control group were studied. After vitamin C administration IMT reduced in all studied groups (P<0.05). FMD increased in all studied groups, but it was significant only in the control group (P=0.02 in the control group and P=0.07 in patients with DM). Mean differences of IMT 2 – IMT 1, FMD 2 – FMD 1 and left ventricular (LV) mass 2 – LV mass 1 and blood pressure (BP) were not significantly different in two studied groups (P>0.05). Mean differences of IMT 2 – IMT 1, FMD 2 – FMD 1, LV mass 2 – LV mass 1 and BP were not significantly different in patients with HbA1c
£ 7 g/dl and those with HbA1c>7 g/dl and control group (P>0.05).
Conclusions: The findings of the current study indicated that vitamin C may have a protective effect on endothelial dysfunction, but regarding its effectiveness among the high-risk population such as diabetic patients with and without appropriate glycemic control the study was not sufficiently powered due to its small sample size.

 
Keyword(s): ENDOTHELIUM, TYPE 1 DIABETES, VITAMIN C
 
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