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Paper Information

Journal:   JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)   AUGUST 2014 , Volume 7 , Number 8; Page(s) 0 To 0.
 
Paper: 

OCCULT HEPATITIS B VIRUS AMONG THE PATIENTS WITH ABNORMAL ALANINE TRANSAMINASE

 
 
Author(s):  MAKVANDI MANOOCHEHR*, NEISI NILOOFAR, KHALAF KHANY DAVOD, MAKVANDI KAMYAR, HAJIANI ESKANDAR, SHAYESTEH ALI AKBAR, MASJEDIZADEH ABDOLRAHIM, SINA AMIR HOSEIN, HAMIDIFARD MOJTABA, RASTI MOJTABA, ARYAN EHSAN, AHMADI KAMBIZ, YADYAD MOHAMMAD JAFAR
 
* INFECTIOUS AND TROPICAL DISEASE RESEARCH CENTER, AHVAZ JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES, AHVAZ, IR IRAN
 
Abstract: 

Background: The occult hepatitis B infection (OBI) is defined as the presence of hepatitis B virus (HBV) DNA in the sera or in the liver biopsy and the absence of hepatitis B surface antigen (HBsAg) by serological test.
Objectives: The current study aimed to evaluate the occult HBV infection by polymerase chain reaction (PCR) and determine HBV genotyping among the patients with abnormal alanine transaminase (ALT) in Ahvaz city, Iran.
Patients and Methods: The sera of 120 patients, 54 (45%) females and 66 (55%) males, with abnormal ALT 40-152 IU were collected. All the patients were negative for HBsAg for more than one year. The patients sera were tested by PCR using primers specified for the S region of HBV. Then the positive PCR products were sequenced to determine HBV genotyping and phylogenic tree.
Results: Of these 120 subjects, 12 (10%) patients including 6 (5%) males and 6 (5%) females were found positive for HBV DNA by PCR, which indicated the presence of occult HBV infection among these patients. The sequencing results revealed that genotype D was predominant with sub-genotyping D1 among OBI patients.
Conclusions: Occult hepatitis B infection is remarkably prevalent in Ahvaz, Iran, and should be considered as a potential risk factor for the transmission of Hepatitis B Virus throughout the community by the carriers.

 
Keyword(s): OCCULT, ALANINE TRANSAMINASE, HEPATITIS B, POLYMERASE CHAIN REACTION
 
 
References: 
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Click to Cite.
APA: Copy

MAKVANDI, M., & NEISI, N., & KHALAF KHANY, D., & MAKVANDI, K., & HAJIANI, E., & SHAYESTEH, A., & MASJEDIZADEH, A., & SINA, A., & HAMIDIFARD, M., & RASTI, M., & ARYAN, E., & AHMADI, K., & YADYAD, M. (2014). OCCULT HEPATITIS B VIRUS AMONG THE PATIENTS WITH ABNORMAL ALANINE TRANSAMINASE. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 7(8), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=408351



Vancouver: Copy

MAKVANDI MANOOCHEHR, NEISI NILOOFAR, KHALAF KHANY DAVOD, MAKVANDI KAMYAR, HAJIANI ESKANDAR, SHAYESTEH ALI AKBAR, MASJEDIZADEH ABDOLRAHIM, SINA AMIR HOSEIN, HAMIDIFARD MOJTABA, RASTI MOJTABA, ARYAN EHSAN, AHMADI KAMBIZ, YADYAD MOHAMMAD JAFAR. OCCULT HEPATITIS B VIRUS AMONG THE PATIENTS WITH ABNORMAL ALANINE TRANSAMINASE. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM). 2014 [cited 2021May10];7(8):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408351



IEEE: Copy

MAKVANDI, M., NEISI, N., KHALAF KHANY, D., MAKVANDI, K., HAJIANI, E., SHAYESTEH, A., MASJEDIZADEH, A., SINA, A., HAMIDIFARD, M., RASTI, M., ARYAN, E., AHMADI, K., YADYAD, M., 2014. OCCULT HEPATITIS B VIRUS AMONG THE PATIENTS WITH ABNORMAL ALANINE TRANSAMINASE. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), [online] 7(8), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408351.



 
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