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Paper Information

Journal:   JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)   JUNE 2014 , Volume 7 , Number 6; Page(s) 0 To 0.
 
Paper: 

INTERFERON-GAMMA AND INTERLUKIN-4 PATTERNS IN BALB/C MICE SUFFERING FROM CUTANEOUS LEISHMANIASIS TREATED WITH CANTHARIDIN

 
 
Author(s):  MAROUFI YAHYA, GHAFFARIFAR FATEMEH*, DALIMI ABDOLHOSSEIN, SHARIFI ZOHREH
 
* DEPARTMENT OF PARASITOLOGY, FACULTY OF MEDICAL SCIENCES, TARBIAT MODARES UNIVERSITY, TEHRAN, IR IRAN
 
Abstract: 

Background: Cutaneous leishmaniasis is a health problem in the world. Lesions should be treated on cosmetically or functionally important sites, such as the face and hands. Cantharidin is a terpenoid compound produced naturally by beetles of Meloidae and Oedemeridae families.
Objectives: The current study aimed to investigate the effect of cantharidin on Cutaneous Leishmaniasis (CL) lesions and IFN-? and IL-4 patterns in infected BALB/c mice.
Materials and Methods: Infected BALB/c mice were divided into five groups as: untreated (control group), eucerin-treated and 0.05%, 0.1% and 0.5% cantharidin-treated. Lesions diameter was measured by Vernier caliper every three days for four weeks. Cytokines levels were measured by enzyme-linked immunosorbent assay (ELISA) using U-CyTech kit.
Results: The results indicated that treatment with cantharidin exacerbates lesions compared with the controls, except for 0.05% cantharidin dose that restrained lesion growth significantly. Interferon gamma level in cantharidin-treated groups was significantly less than that of the control group. But interlukin-4 level was similar among the groups.
Conclusions: The current study results indicated that high doses of cantharidin exacerbates leishmaniasis lesion, but low dose of cantharidin inhibits lesion growth.

 
Keyword(s): MICE, INBRED BALB/C, CANTHARIDIN, LEISHMANIASIS, CUTANEOUS, INTERFERON-GAMMA
 
 
References: 
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+ Click to Cite.
APA: Copy

MAROUFI, Y., & GHAFFARIFAR, F., & DALIMI, A., & SHARIFI, Z. (2014). INTERFERON-GAMMA AND INTERLUKIN-4 PATTERNS IN BALB/C MICE SUFFERING FROM CUTANEOUS LEISHMANIASIS TREATED WITH CANTHARIDIN. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 7(6), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=408334



Vancouver: Copy

MAROUFI YAHYA, GHAFFARIFAR FATEMEH, DALIMI ABDOLHOSSEIN, SHARIFI ZOHREH. INTERFERON-GAMMA AND INTERLUKIN-4 PATTERNS IN BALB/C MICE SUFFERING FROM CUTANEOUS LEISHMANIASIS TREATED WITH CANTHARIDIN. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM). 2014 [cited 2021May16];7(6):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408334



IEEE: Copy

MAROUFI, Y., GHAFFARIFAR, F., DALIMI, A., SHARIFI, Z., 2014. INTERFERON-GAMMA AND INTERLUKIN-4 PATTERNS IN BALB/C MICE SUFFERING FROM CUTANEOUS LEISHMANIASIS TREATED WITH CANTHARIDIN. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), [online] 7(6), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408334.



 
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