Paper Information

Journal:   INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE   2014 , Volume 5 , Number 8; Page(s) 1037 To 1044.
 
Paper: 

IRON AND VITAMIN C CO?SUPPLEMENTATION INCREASED SERUM VITAMIN C WITHOUT ADVERSE EFFECT ON ZINC LEVEL IN IRON DEFICIENT FEMALE YOUTH

 
 
Author(s):  KHOSHFETRAT MOHAMMAD REZA, MORTAZAVI SIMA, NEYESTANI TIRANG, MAHMOODI MOHAMMAD REZA, ZERAFATI SHOAE NAHID, MOHAMMADI NASRABADI FATEMEH*
 
* 7, WEST ARGHAVAN STREET, FARAHZADI BLVD., TEHRAN 1981619573, IRAN
 
Abstract: 

Background: Iron supplementation can decrease the absorption of zinc and influence other antioxidants levels such as vitamin C. This study aimed to investigate the effect of iron supplements alone and in combination with vitamin C on zinc and vitamin C status in iron deficient female students.
Methods: In a double-blind randomized clinical trail, 60 iron deficient students were selected from 289 volunteers residing in dormitory. After matching, subjects were randomly assigned into two groups: Group I (50 mg elemental iron supplements) and Group II (50 mg elemental iron+500 mg ascorbic acid). Serum ferritin, iron, serum zinc, and plasma vitamin C concentrations were measured by using enzyme-linked immunosorbent assay, spectrophotometer, atomic absorption spectrometer, and colorimeter, respectively after 6 and 12 weeks supplementation. Student’s t -test and repeated measures analysis of variance were applied to analyze the data using SPSS software.
Results: Serum zinc levels had no significant differences between 2 groups at the baseline; however, its concentration decreased from 80.9 ± 4.2-68.9 ± 2.7
mg/dl to 81.2 ± 4.5-66.1 ± 2.9 mg/dl (P<0.001) in Groups I and II, respectively after 6 weeks of supplementation. Continuous supplementation increased serum zinc concentration to baseline levels (79.0 ± 2.9 mg/dl; P<0.01) in Group I and 70.5 ± 3.1 mg/dl in Group II following 12 weeks of supplementation. Plasma vitamin C increased from 3 ± 0/1-3.3 ± 0.2 mg/dl to 2.7 ± 0.1-4.2 ± 0.2 mg/dl (P<0.01) in Groups I and II, respectively. At the end of study, plasma vitamin C significantly increased from 3.3 ± 0.3-4.7 ± 0.3 (P<0.01) to 4.2 ± 0.2-7.1 ± 0.2 (P<0.001) in Groups I and II, respectively.
Conclusions: Iron supplementation with and without vitamin C led to reduction in serum Zn in iron-deficient female students after 6 weeks. However, the decreasing trend stops after repletion of iron stores and Zn levels returned to the approximately baseline values after 12 weeks.

 
Keyword(s): FEMALE, IRON DEFICIENCY, IRON SUPPLEMENTATION, SERUM ZINC, VITAMIN C
 
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