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Paper Information

Journal:   IRANIAN JOURNAL OF PATHOLOGY (IJP)   FALL 2013 , Volume 8 , Number 4; Page(s) 255 To 262.
 
Paper: 

EVALUATION OF POSSIBLE ROLE OF DENDRITIC CELLS IN VARIOUS LUPUS NEPHRITIS

 
 
Author(s):  DABIRI SHAHRIAR*, ZAKERIDANA HADISEH, SHAMSI MEYMANDI MANZUMEH, ETMINAN ABBAS, AZMANDIAN JALAL, HABIBZADEH SIMINDOKHET, KHAZANFARI FARZANEH, PARVARESH SAEEDEH
 
* DEPARTMENT OF PATHOLOGY AFZALIPOUR MEDICAL SCHOOL, NEPHROLOGY-PHYSIOLOGY RESEARCH CENTER, KERMAN, IRAN
 
Abstract: 

Background & Objectives: Chronicity of lupus nephritis (LN) should be considered for interaction of cell mediated immunity (CMI) and dendritic cells in glomeruli and tubulointerstitial areas. In this study establishment of immunohistopathological changes of dendritic cells and other immune effector cells in lupus nephritis comparing with non-lupus nephritis was performed.
Materials & Methods: Renal needle biopsies of 35 cases of lupus nephritis and 35 cases of other causes of persistent proteinuria were compared for immunohistochemistry for plasmacytoid (CD123), myeloid (CD11c) dendritic cells, macrophages (CD68) and lymphocytes (CD4) markers. Statistical analysis of the data was performed using Spearman and Pearson correlation or ANOVA and t-student test (P<0.05).
Results: Significant difference of glomerular and interstitial spaces for presence of myeloid-plasmacytoid dendritic cells and lymphocytes except macrophages between lupus nephritis and other causes of persistent proteinuria have found (P<0.001). Positive significant correlations were observed between glomerular presentation of myeloid dendritic cells and chronicity index but not with other markers in lupus nephritis (P<0.001). Statistically significant changes between presence of all markers and activity index were not observed (P>0.05).
Conclusions: The myeloid dendritic cells might have synergistic role with other immune cells in pathogenesis and progression or chronicity of lupus nephritis.

 
Keyword(s): LUPUS GLOMERULONEPHRITIS, DENDRITIC CELL
 
 
References: 
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+ Click to Cite.
APA: Copy

DABIRI, S., & ZAKERIDANA, H., & SHAMSI MEYMANDI, M., & ETMINAN, A., & AZMANDIAN, J., & HABIBZADEH, S., & KHAZANFARI, F., & PARVARESH, S. (2013). EVALUATION OF POSSIBLE ROLE OF DENDRITIC CELLS IN VARIOUS LUPUS NEPHRITIS. IRANIAN JOURNAL OF PATHOLOGY (IJP), 8(4), 255-262. https://www.sid.ir/en/journal/ViewPaper.aspx?id=408308



Vancouver: Copy

DABIRI SHAHRIAR, ZAKERIDANA HADISEH, SHAMSI MEYMANDI MANZUMEH, ETMINAN ABBAS, AZMANDIAN JALAL, HABIBZADEH SIMINDOKHET, KHAZANFARI FARZANEH, PARVARESH SAEEDEH. EVALUATION OF POSSIBLE ROLE OF DENDRITIC CELLS IN VARIOUS LUPUS NEPHRITIS. IRANIAN JOURNAL OF PATHOLOGY (IJP). 2013 [cited 2021May18];8(4):255-262. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408308



IEEE: Copy

DABIRI, S., ZAKERIDANA, H., SHAMSI MEYMANDI, M., ETMINAN, A., AZMANDIAN, J., HABIBZADEH, S., KHAZANFARI, F., PARVARESH, S., 2013. EVALUATION OF POSSIBLE ROLE OF DENDRITIC CELLS IN VARIOUS LUPUS NEPHRITIS. IRANIAN JOURNAL OF PATHOLOGY (IJP), [online] 8(4), pp.255-262. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408308.



 
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