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Paper Information

Journal:   ADVANCED PHARMACEUTICAL BULLETIN   2014 , Volume 4 , Number 1; Page(s) 35 To 42.
 
Paper: 

ANXIOGENIC EFFECTS OF ACUTE INJECTION OF SESAME OIL MAY BE MEDIATED BY β-1 ADRENOCEPTORS IN THE BASOLATERAL AMYGDALA

 
 
Author(s):  KESMATI MAHNAZ, MARD SOLTANI MAYSAM*, KHAJEHPOUR LOTFOLAH
 
* DEPARTMENT OF BIOLOGY, FACULTY OF SCIENCE, SHAHID CHAMRAN UNIVERSITY, AHVAZ, IRAN
 
Abstract: 

Purpose: A few studies have indicates that the sesame oil influences anxiety, but many reports show that b-1 adrenoceptors (ARs) of the basolateral amygdala (BLA) plays a pivotal role in this regard. Therefore, in this study the effect of acute injection of sesame oil on anxiety-like behavior in the presence and absence of the BLA b-1 ARs in the male Wistar rats were investigated.
Methods: Guide cannulas, for seven groups of rats, were implanted bilaterally into the BLA. Two weeks after the stereotaxic surgery, anxiety-like behaviors (the OAT%, OAE % and locomotor activity) were evaluated by Elevated Plus-Maze (EPM) for all groups.3 groups received different volumes of sesame oil (i.p.) and they were compared with control group (received saline via i.p.), and the anxiogenic volume of sesame oil (1.5ml/kg) was determined. Then, 3 other groups received constant effective volume of sesame oil (1.5ml/kg) along with 3 different doses of betaxolol, selective
b-1 ARs antagonist, intra BLA microinjection in order to be compared with sesame oil group (1.5 ml/kg).
Results: The acute injection of sesame oil with the volume dependent manner showed an anxiogenic effect with reduction of the OAT% and OAE% which the maximum effect of sesame oil was observed in the dose of 1.5mg/kg. Also, betaxolol with dose dependent manner attenuated the anxiogenic effects of sesame oil (1.5mg/kg), but this reduction could not remove the anxiety effects completely.
Conclusion: It seems that the sesame oil acute (i.p.) injection induces anxiety, and this effect is attenuated by inhibition of
b-1ARs in the BLA

 
Keyword(s): SESAME OIL, ANXIETY, β-1 ADRENOCEPTORS, BASOLATERAL AMYGDALA, ELEVATED PLUS-MAZE
 
 
References: 
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APA: Copy

KESMATI, M., & MARD SOLTANI, M., & KHAJEHPOUR, L. (2014). ANXIOGENIC EFFECTS OF ACUTE INJECTION OF SESAME OIL MAY BE MEDIATED BY β-1 ADRENOCEPTORS IN THE BASOLATERAL AMYGDALA. ADVANCED PHARMACEUTICAL BULLETIN, 4(1), 35-42. https://www.sid.ir/en/journal/ViewPaper.aspx?id=408298



Vancouver: Copy

KESMATI MAHNAZ, MARD SOLTANI MAYSAM, KHAJEHPOUR LOTFOLAH. ANXIOGENIC EFFECTS OF ACUTE INJECTION OF SESAME OIL MAY BE MEDIATED BY β-1 ADRENOCEPTORS IN THE BASOLATERAL AMYGDALA. ADVANCED PHARMACEUTICAL BULLETIN. 2014 [cited 2021May18];4(1):35-42. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408298



IEEE: Copy

KESMATI, M., MARD SOLTANI, M., KHAJEHPOUR, L., 2014. ANXIOGENIC EFFECTS OF ACUTE INJECTION OF SESAME OIL MAY BE MEDIATED BY β-1 ADRENOCEPTORS IN THE BASOLATERAL AMYGDALA. ADVANCED PHARMACEUTICAL BULLETIN, [online] 4(1), pp.35-42. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408298.



 
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