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Paper Information

Journal:   IRANIAN JOURNAL OF PATHOLOGY (IJP)   FALL 2013 , Volume 8 , Number 4; Page(s) 235 To 240.
 
Paper: 

ROLE OF CYCLOOXYGENESE-2 (COX-2) EXPRESSION IN BREAST CANCER DIFFERENTIATION AND ITS RELATIONSHIP WITH HORMONE RECEPTORS STATUS

 
 
Author(s):  GHAHREMANFARD FARAHNAZ*, ALAVY TOUSSY JAFAR, KAZEMINEZHAD BEHRANG, RAMEZANI FARZANEH
 
* DEPARTMENT OF INTERNAL MEDICINE, SEMNAN UNIVERSITY OF MEDICAL SCIENCE, SEMNAN, IRAN
 
Abstract: 

Background and Objectives: Cyclooxygenese-2 (COX-2) expression in breast cancer and its correlation with tumor prognosis is unclear. We investigated the incidence of COX-2 expression in patients and assessed interactions between COX-2 and clinical features of cancer and expression of HER2/neu, estrogen receptor (ER), and progesterone receptor (PR).
Methods: COX-2 expression was investigated by immunohistochemistry in 29 patients’ specimens diagnosed as primary breast cancer between 2006 and 2008 at the Fatemieh Hospital, Semnan, Iran. Relationship between COX-2 expression and age, histological grade, histological type, nodal status, and hormone receptor status were evaluated.
Results: We used IHC method although it was not a quantitative study. Its expression depends on quality of antibody, staining and selection of analyzed region. COX-2, HER-2, ER, and PR were detected in 89.7%, 51.7%, 82.8%, and 79.3% of samples, respectively. Elevated COX-2 expression was not associated with size and grade of tumor, while mean numbers of involved lymph nodes was significantly higher in those with elevated expression of COX-2 (P=0.001). There were no significant correlations between COX-2 expression and HER-2, ER, and PR receptors.
Conclusion: Only tumor tissue was analyzed and did not compare to normal tissue. Elevated COX-2 expression can be found in most patients with breast cancer and has a crucial role in tumor differentiation regarding degree of lymph node involvement. It seems that correlation between COX-2 and other oncogens and hormonal receptors might be influenced by geographical and racial factors, so, assessment of these relationships in each patient’s population may be necessary.

 
Keyword(s): CYCLOOXYGENASE-2, BREAST CANCER, ESTROGEN RECEPTORS, PROGESTERONE RECEPTOR, HER-2 PROTO-ONCOGENE PROTEIN
 
 
References: 
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Click to Cite.
APA: Copy

GHAHREMANFARD, F., & ALAVY TOUSSY, J., & KAZEMINEZHAD, B., & RAMEZANI, F. (2013). ROLE OF CYCLOOXYGENESE-2 (COX-2) EXPRESSION IN BREAST CANCER DIFFERENTIATION AND ITS RELATIONSHIP WITH HORMONE RECEPTORS STATUS. IRANIAN JOURNAL OF PATHOLOGY (IJP), 8(4), 235-240. https://www.sid.ir/en/journal/ViewPaper.aspx?id=408280



Vancouver: Copy

GHAHREMANFARD FARAHNAZ, ALAVY TOUSSY JAFAR, KAZEMINEZHAD BEHRANG, RAMEZANI FARZANEH. ROLE OF CYCLOOXYGENESE-2 (COX-2) EXPRESSION IN BREAST CANCER DIFFERENTIATION AND ITS RELATIONSHIP WITH HORMONE RECEPTORS STATUS. IRANIAN JOURNAL OF PATHOLOGY (IJP). 2013 [cited 2021May07];8(4):235-240. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408280



IEEE: Copy

GHAHREMANFARD, F., ALAVY TOUSSY, J., KAZEMINEZHAD, B., RAMEZANI, F., 2013. ROLE OF CYCLOOXYGENESE-2 (COX-2) EXPRESSION IN BREAST CANCER DIFFERENTIATION AND ITS RELATIONSHIP WITH HORMONE RECEPTORS STATUS. IRANIAN JOURNAL OF PATHOLOGY (IJP), [online] 8(4), pp.235-240. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408280.



 
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