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Paper Information

Journal:   INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)   JUNE 2014 , Volume 12 , Number 6; Page(s) 415 To 420.
 
Paper: 

VAGIFEM IS SUPERIOR TO VAGINAL PREMARIN IN INDUCTION OF ENDOMETRIAL THICKNESS IN THE FROZEN-THAWED CYCLE PATIENTS WITH REFRACTORY ENDOMETRIA: A RANDOMIZED CLINICAL TRIAL

 
 
Author(s):  ZOLGHADRI JALEH, HAGHBIN HOSSEIN*, DADRAS NASRIN, BEHDIN SHABNAM
 
* INFERTILITY RESEARCH CENTER, GHADIR HOSPITAL, GOLSHAN TOWN, SHIRAZ, IRAN
 
Abstract: 

Background: Embryo transfer to a developed endometrium is an important prognostic factor in frozen-thawed embryo transfer cycle outcome. Vaginal estrogen, such as Vagifem vaginal tablets and Premarin vaginal cream, is a regimen used for the patients with refractive endometria.
Objective: Our objective was to compare the effects of Vagifem and Premarin on the endometrial thickness of the patients with refractive endometria.
Materials and Methods: In this randomized clinical trial, 30 patients with refractive endometria in frozen-thawed embryo transfer cycles received Vagifem vaginal tablets and 30 women received Premarin vaginal cream. Endometrial thickness was measured on the 14th day of drug administration.
Results: Comparing the endometrial thicknesses of the two groups showed that the endometria of the Vagifem group was significantly thicker than that of the Premarin group (5.93
±0.38 vs. 6.74±0.32; p<0.001).
Conclusion: Vagifem is superior to Premarin in induction of endometrial thickness in frozen-thawed embryo transfer cycles in the patients with refractive endometria.

 
Keyword(s): PREMARIN, ESTRADIOL, ENDOMETRIUM, INFERTILITY, HUMAN
 
References: 
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