Paper Information

Journal:   INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)   JUNE 2014 , Volume 12 , Number 6; Page(s) 401 To 408.
 
Paper: 

PROTECTIVE EFFECT OF URTICA DIOICA L AGAINST NICOTINE-INDUCED DAMAGE ON SPERM PARAMETERS, TESTOSTERONE AND TESTIS TISSUE IN MICE

 
 
Author(s):  JALILI CYRUS, SALAHSHOOR MOHAMMAD REZA*, NASERI ALI
 
* FERTILITY AND INFERTILITY RESEARCH CENTER, KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES, DANESHGAH AVE., TAGHBOSTAN, KERMANSHAH, IRAN
 
Abstract: 

Background: Nicotine consumption can decrease fertility drive in males by inducing oxidative stress and DNA damage. Urtica dioica L (U.dioica) is a multipurpose herb in traditional medicine for which some anti-oxidative and anti-inflammatory properties have been identified.
Objective: The main goal is to investigate whether the U.dioica could inhibit nicotine adverse effects on sperm cells viability, count, motility, and testis histology and testosterone hormone.
Materials and Methods: In this study, hydro-alcoholic extract of U.dioica was prepared and various doses of U.dioica (0, 10, 20, and 50 mg/kg) and U.dioica plus nicotine (0, 10, 20, and 50 mg/kg) were administered intraperitoneally to 56 male mice for 28 consequent days. These mice were randomly assigned to 8 groups (n=7) and sperm parameters (sperm cells viability, count, motility, and morphology), testis and prostate weight, testis histology and testosterone hormone were analyzed and compared.
Results: The results indicated that nicotine administration (0.5 mg/kg) significantly decreased testosterone level, count and motility of sperm cells, and testis weight compared to control group (p=0.00). However, increasing the dose of U.dioica significantly boosted motility, count, normal morphology of sperm cells, seminiferous tubules diameter, and testosterone in all groups compared to control (p=0.00) and testis weight in 20 and 50 mg/kg doses in comparison with control group (p=0.00).
Conclusion: It seems that U.dioica hydro-alcoholic extract administration could increase the quality of spermatozoa and inhibits nicotine-induced adverse effects on sperm parameters.

 
Keyword(s): U.DIOICA L, NICOTINE, SPERM PARAMETERS, MICE
 
References: 
  • ندارد
 
  pdf-File tarjomyar Yearly Visit 88
 
Latest on Blog
Enter SID Blog