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Paper Information

Journal:   INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE   2014 , Volume 5 , Number 3; Page(s) 262 To 268.
 
Paper: 

ROLES OF THE NUCLEUS ACCUMBENS (SHELL) IN THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED CONDITIONED BEHAVIOR IN FREELY MOVING RATS

 
 
Author(s):  KARIMI SARA, RADAHMADI MARYAM, FAZILATI MOHAMMAD, AZIZI MALEKABADI HAMID, ALAEI HOJJATALLAH*
 
* DEPARTMENT OF PHYSIOLOGY, SCHOOL OF MEDICINE, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, IRAN
 
Abstract: 

Background: The nucleus accumbens (NAc) is a part of the rewarding cortico-mesolimbic dopamine (DA) pathway. This is a heterogeneous structure divided in two sub regions termed core and shell. DA function in the NAc is critical for goal-oriented behaviors, including those motivated by drug and brain stimulation reward. In the conditioned-place preference (CPP) paradigm, a test assessing animal’s ability to associate drug-induced effects with environmental cause to quantify drug reward for example morphine.
Methods: In the present study, we investigated the influence of electrical stimulation with different current intensities on (25 and 100
mA) with and without an effective dose of morphine (0.5 and 5 mg/kg) on CPP. Results: Subcutaneous administration of morphine 5 mg/kg produced significant CPP in comparison with saline group. Our findings also showed that electrical stimulation of NAc (100 mA) significantly (P<0.01) suppressed morphine-induced CPP that reveals impaired learning and memory formation in the process of conditioning. We found that morphine-induced CPP can be successfully suppressed by current intensity (100 mA). It was probably due to decreasing of dopamine contents and its metabolites in the NAc. Current intensity (100 mA) in combination with ineffective dose of morphine (0.5 mg/kg) increased morphine-induced CPP probability via the prove reward system.
Conclusions: Since stimulation of dopaminergic neurons increases tendency to dependence to morphine, therefore in the present study, the stimulation of the NAc suppressed morphine-induced CPP that this shows impairment of learning and memory formation.

 
Keyword(s): CONDITIONED-PLACE PREFERENCE, MORPHINE, NUCLEUS ACCUMBENS, RAT
 
 
References: 
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Click to Cite.
APA: Copy

KARIMI, S., & RADAHMADI, M., & FAZILATI, M., & AZIZI MALEKABADI, H., & ALAEI, H. (2014). ROLES OF THE NUCLEUS ACCUMBENS (SHELL) IN THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED CONDITIONED BEHAVIOR IN FREELY MOVING RATS. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, 5(3), 262-268. https://www.sid.ir/en/journal/ViewPaper.aspx?id=408202



Vancouver: Copy

KARIMI SARA, RADAHMADI MARYAM, FAZILATI MOHAMMAD, AZIZI MALEKABADI HAMID, ALAEI HOJJATALLAH. ROLES OF THE NUCLEUS ACCUMBENS (SHELL) IN THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED CONDITIONED BEHAVIOR IN FREELY MOVING RATS. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE. 2014 [cited 2021May11];5(3):262-268. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408202



IEEE: Copy

KARIMI, S., RADAHMADI, M., FAZILATI, M., AZIZI MALEKABADI, H., ALAEI, H., 2014. ROLES OF THE NUCLEUS ACCUMBENS (SHELL) IN THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED CONDITIONED BEHAVIOR IN FREELY MOVING RATS. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, [online] 5(3), pp.262-268. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408202.



 
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