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Paper Information

Journal:   INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)   JUNE 2014 , Volume 12 , Number 6; Page(s) 395 To 400.
 
Paper: 

INVESTIGATION ON ESTROGEN RECEPTOR ALPHA GENE POLYMORPHISMS IN IRANIAN WOMEN WITH RECURRENT PREGNANCY LOSS

 
 
Author(s):  MAHDAVIPOUR MARZIEH, IDALI FARAH, ZAREI SAEED, TALEBI SAEED, FATEMI RAMINA, JEDDI TEHRANI MAHMOOD, PAHLAVAN SOMAYEH, RAJAEI FARZAD*
 
* CELL AND MOLECULAR RESEARCH CENTRE, QAZVIN UNIVERSITY OF MEDICAL SCIENCES, QAZVIN, IRAN
 
Abstract: 

Background: Recurrent pregnancy loss (RPL) is a multifactorial disorder. Environmental factors and genetics can affect pregnancy outcomes.
Objective: Conflicting data suggest an association between estrogen receptor alpha (ESR1) gene polymorphisms and RPL. In this study, such association was investigated in Iranian women with RPL.
Materials and Methods: In this case control study, blood samples were collected from 244 women with a history of three or more consecutive pregnancy losses and 104 healthy women with at least two live births. Using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), we studied -397C/T and -351A/G polymorphisms on ESR1 gene in case and control subjects.
Results: The genotypic frequencies of -397C/T and -351A/G polymorphisms on ESR1were not significantly different between RPL and control groups (p=0.20 and p=0.09, respectively). A significantly negative correlation was observed between -397C/T and -351A/G (r=-0.852, p<0.001) in RPL women and complete linkage disequilibrium between the investigated polymorphisms was found (D': 0.959; r-square= 0.758, p<0.001).
Conclusion: This investigation suggests that the analyzed polymorphisms on ESR1gene are not associated with an increased risk of RPL in the studied population.

 
Keyword(s): ESTROGEN RECEPTOR, POLYMORPHISM, ABORTION, RECURRENT
 
 
References: 
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Click to Cite.
APA: Copy

MAHDAVIPOUR, M., & IDALI, F., & ZAREI, S., & TALEBI, S., & FATEMI, R., & JEDDI TEHRANI, M., & PAHLAVAN, S., & RAJAEI, F. (2014). INVESTIGATION ON ESTROGEN RECEPTOR ALPHA GENE POLYMORPHISMS IN IRANIAN WOMEN WITH RECURRENT PREGNANCY LOSS. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 12(6), 395-400. https://www.sid.ir/en/journal/ViewPaper.aspx?id=408194



Vancouver: Copy

MAHDAVIPOUR MARZIEH, IDALI FARAH, ZAREI SAEED, TALEBI SAEED, FATEMI RAMINA, JEDDI TEHRANI MAHMOOD, PAHLAVAN SOMAYEH, RAJAEI FARZAD. INVESTIGATION ON ESTROGEN RECEPTOR ALPHA GENE POLYMORPHISMS IN IRANIAN WOMEN WITH RECURRENT PREGNANCY LOSS. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE). 2014 [cited 2021May12];12(6):395-400. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408194



IEEE: Copy

MAHDAVIPOUR, M., IDALI, F., ZAREI, S., TALEBI, S., FATEMI, R., JEDDI TEHRANI, M., PAHLAVAN, S., RAJAEI, F., 2014. INVESTIGATION ON ESTROGEN RECEPTOR ALPHA GENE POLYMORPHISMS IN IRANIAN WOMEN WITH RECURRENT PREGNANCY LOSS. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), [online] 12(6), pp.395-400. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408194.



 
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