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Paper Information

Journal:   IRANIAN JOURNAL OF PATHOLOGY (IJP)   SUMMER 2013 , Volume 8 , Number 3; Page(s) 204 To 208.
 
Paper: 

LEUKOCYTE ADHESION DEFICIENCY TYPE 1 PRESENTING AS LEUKEMOID REACTION (CASE REPORT)

 
 
Author(s):  AHMAD SHARIQUE, AHMAD KHAN SUFIA*, SHINGLA SHIVAM, BHATNAGAR SHIRISH, AHMAD KHAN KABEER
 
* DEPARTMENT OF PATHOLOGY, ERA’S LUCKNOW MEDICAL COLLEGE AND HOSPITAL, HARDOI ROAD, LUCKNOW, INDIA
 
Abstract: 

The hallmarks of leukocyte adhesion deficiency (LAD) are defects in the leukocyte adhesion process, marked leukocytosis and recurrent infections. These molecular and clinical manifestations result from an impaired step in the inflammatory process, namely, the emigration of leukocytes from the blood vessels to sites of infection, which requires adhesion of leukocytes to the endothelium. Over last 20 years, three distinctive defects in the leukocyte adhesion cascade, involving several precise ordered steps such as rolling, integrin activation and firm adhesion of the leukocytes have been described. While LAD I and II are clearly autosomal recessive disorders, the mode of inheritance of LAD III is still not clear. LAD I is due to structural defects in the integrin molecule, preventing firm adhesion to occur. We present a case of a male neonate referred with continuation of leukemoid reaction and multiple non healing ulcers, gingivitis and periodontitis in spite of good antibiotic therapy.

 
Keyword(s): LEUKOCYTE ADHESION DEFICIENCY SYNDROME, LEUKEMOID REACTION, NEONATE
 
 
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Click to Cite.
APA: Copy

AHMAD, S., & AHMAD KHAN, S., & SHINGLA, S., & BHATNAGAR, S., & AHMAD KHAN, K. (2013). LEUKOCYTE ADHESION DEFICIENCY TYPE 1 PRESENTING AS LEUKEMOID REACTION (CASE REPORT). IRANIAN JOURNAL OF PATHOLOGY (IJP), 8(3), 204-208. https://www.sid.ir/en/journal/ViewPaper.aspx?id=408192



Vancouver: Copy

AHMAD SHARIQUE, AHMAD KHAN SUFIA, SHINGLA SHIVAM, BHATNAGAR SHIRISH, AHMAD KHAN KABEER. LEUKOCYTE ADHESION DEFICIENCY TYPE 1 PRESENTING AS LEUKEMOID REACTION (CASE REPORT). IRANIAN JOURNAL OF PATHOLOGY (IJP). 2013 [cited 2021May11];8(3):204-208. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408192



IEEE: Copy

AHMAD, S., AHMAD KHAN, S., SHINGLA, S., BHATNAGAR, S., AHMAD KHAN, K., 2013. LEUKOCYTE ADHESION DEFICIENCY TYPE 1 PRESENTING AS LEUKEMOID REACTION (CASE REPORT). IRANIAN JOURNAL OF PATHOLOGY (IJP), [online] 8(3), pp.204-208. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408192.



 
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