Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   IRANIAN JOURNAL OF PATHOLOGY (IJP)   FALL 2014 , Volume 9 , Number 4; Page(s) 245 To 250.
 
Paper: 

THE USEFULNESS OF CD10 IN DISTINGUISHING BETWEEN CUTANEOUS BASAL CELL CARCINOMA AND SQUAMOUS CELL CARCINOMA

 
 
Author(s):  SABETI SHAHRAM, MALEKZAD FARHAD, NEISHABOORI NASTARAN, POURABDOLLAH TOUTKABONI MIHAN*, BIDARIZEREHPOOSH FARAHNAZ
 
* CHRONIC RESPIRATORY DISEASES RESEARCH CENTER, NRITLD, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Background & Objectives: CD10 is a cell surface enzyme with metalloendopeptidase activity, also known as Common Acute Lymphoblastic Leukaemia Antigen, which mainly serves as a marker for acute lymphoblastic leukemia (ALL). To date and to the best of our knowledge, only few comparative immunohistochemical studies have assessed CD10 expression in cutaneous epithelial neoplasms. Our goal was to determine whether CD10 can be used in pathologic distinction of cutaneous basal cell carcinoma (BCC) and squamous cell carcinoma (SCC).
Methods: This study included 27 BCC and 17 SCC cases immunohistochemically stained for CD10. Cytoplasmic +/- cell membrane staining was considered as positive. Each slide was studied by two pathologists and scored semi- quantitatively as follows: negative (<10%); 1+ (10-50% positive cells); and 2+ (>50% positive cells).
Results: The rate of CD10 expression in tumor cells was significantly higher in BCCs in comparison to SCCs. (20.27 vs., 2.17; P<0.0001).
Discussion: Our findings suggest CD10 as a useful adjunct marker in distinguishing cutaneous BCC and SCC.

 
Keyword(s): BASAL CELL CARCINOMA, SQUAMOUS CELL CARCINOMA, ANTIGEN CD100
 
 
References: 
  • ندارد
  •  
 
Click to Cite.
APA: Copy

SABETI, S., & MALEKZAD, F., & NEISHABOORI, N., & POURABDOLLAH TOUTKABONI, M., & BIDARIZEREHPOOSH, F. (2014). THE USEFULNESS OF CD10 IN DISTINGUISHING BETWEEN CUTANEOUS BASAL CELL CARCINOMA AND SQUAMOUS CELL CARCINOMA. IRANIAN JOURNAL OF PATHOLOGY (IJP), 9(4), 245-250. https://www.sid.ir/en/journal/ViewPaper.aspx?id=408174



Vancouver: Copy

SABETI SHAHRAM, MALEKZAD FARHAD, NEISHABOORI NASTARAN, POURABDOLLAH TOUTKABONI MIHAN, BIDARIZEREHPOOSH FARAHNAZ. THE USEFULNESS OF CD10 IN DISTINGUISHING BETWEEN CUTANEOUS BASAL CELL CARCINOMA AND SQUAMOUS CELL CARCINOMA. IRANIAN JOURNAL OF PATHOLOGY (IJP). 2014 [cited 2021May12];9(4):245-250. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408174



IEEE: Copy

SABETI, S., MALEKZAD, F., NEISHABOORI, N., POURABDOLLAH TOUTKABONI, M., BIDARIZEREHPOOSH, F., 2014. THE USEFULNESS OF CD10 IN DISTINGUISHING BETWEEN CUTANEOUS BASAL CELL CARCINOMA AND SQUAMOUS CELL CARCINOMA. IRANIAN JOURNAL OF PATHOLOGY (IJP), [online] 9(4), pp.245-250. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408174.



 
  pdf-File
Yearly Visit 37
 
Latest on Blog
Enter SID Blog