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Paper Information

Journal:   INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)   JULY 2014 , Volume 12 , Number 3; Page(s) 1 To 4.
 
Paper: 

ALTERATION OF LIPID PARAMETERS IN PATIENTS WITH SUBCLINICAL HYPOTHYROIDISM

 
 
Author(s):  LAWAY BASHIRAHMAD*, WAR FAYAZ AHMAD, SHAH SONAULLAH, MISGAR RAIZ AHMAD, KUMAR KOTWAL SUMAN
 
* DEPARTMENT OF ENDOCRINOLOGY, SHERI KASHMIR INSTITUTE OF MEDICAL SCIENCES, SOURA, SRINAGAR, KASHMIR INDIA
 
Abstract: 
Background: Overt hypothyroidism is associated with abnormalities of lipid metabolism, but conflicting results regarding the degree of lipid changes in subclinical hypothyroidism (SCH) exist.
Objectives: The aim of this study was to assess differences in lipid profile parameters between subjects with and without SCH in a north Indian population.
Patients and Methods: Serum lipid parameters of 70 patients with subclinical hypothyroidism and 100 age and sex matched euthyroid controls were evaluated in a cross-sectional study.
Results: Mean serum total cholesterol (TC), triglycerides (TG) and very low-density cholesterol (VLDL) were significantly higher in patients with SCH than controls (P<0.05). Mean TC, TG and low-density cholesterol (LDL) concentrations were higher in patients with serum thyroid stimulating hormone (TSH) greater than 10 mU/L than those with serum TSH equal to or less than 10 mU/L, but this difference was not statistically significant. No association was found between serum high-density cholesterol (HDL-C) concentration and serum TSH level.
Conclusions: High TC, TG and VLDL were observed in our patients with SCH.
 
Keyword(s): HYPOTHYROIDISM, LIPIDS, HYPOTHYROIDISM
 
References: 
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