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Paper Information

Journal:   IRANIAN JOURNAL OF PATHOLOGY (IJP)   WINTER 2015 , Volume 10 , Number 1; Page(s) 74 To 78.
 
Paper: 

INTRATHORACIC MALIGNANT PERIPHERAL NERVE SHEATH TUMOR: HISTOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL FEATURES: (CASE REPORT)

 
 
Author(s):  SUNITA SINGH, RALLI MEGHA*, HASIJA SONIA, VERMA RENUKA
 
* DEPARTMENTOF PATHOLOGY, POST GRADUATE INSTITUTE OF MEDICAL SCIENCES, ROHTAK, HARYANA, INDIA
 
Abstract: 

Malignant peripheral nerve sheath tumor (MPNST) is a rare nerve sheath tumor derived from Schwann cells or pleuripotent cells of neural crest. Neurogenic tumors make about 10-20% of all mediastinal tumors. Incidence of MPNST is 0.001% in general population and 0.16% in patients with neurofibromatosis I (NF I). We report a case of 60 year female presenting with progressive cough and breathlessness for2 years. The CECT revealed multiple focal enhancing lesions along inferior mediastinal pleural surface and along lateral pleural surface. A thoracotomy and tumor excision was done and MPNST was diagnosed on microscopy and immunohistochemistry. This case highlights that this unusual tumor may involve lung parenchyma. So this possibility should be kept in mind in patients with intrathoracic mass.

 
Keyword(s): PERIPHERAL NERVE SHEATH TUMOR, MEDIASTINUM, CANCER, INDIA
 
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