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Paper Information

Journal:   IRANIAN JOURNAL OF PEDIATRICS   AUGUST 2014 , Volume 24 , Number 4; Page(s) 365 To 370.
 
Paper: 

MORBIDITY AND MORTALITY IN IRANIAN CHILDREN WITH JUVENILE SYSTEMIC LUPUS ERYTHEMATOSUS

 
 
Author(s):  TAVANGAR RAD FARIBA, ZIAEE VAHID*, MORADINEJAD MOHAMMAD HASSAN, TAHGHIGHI FATEMEH
 
* DIVISION OF PEDIATRIC RHEUMATOLOGY, CHILDREN’S MEDICAL CENTER, NO. 62, DR GHARIB ST., KESHAVARZ BLVD., TEHRAN, IRAN
 
Abstract: 

Objective: Juvenile systemic lupus erythematosus (JSLE) is a common rheumatologic disorder that involves multi organ systems. Prognosis of lupus in children may be poorer than in adults. In this study, we determined mortality and morbidity rates in the pediatric SLE in Iran.
Methods: In a cross sectional study, we evaluated 120 children with SLE who had registered in our pediatric rheumatology database within 2004-2010. Data including sex, age, remission, age at the time of diagnosis, age at the time of study, various types of organ involvement, mortality and remission were extracted from this database.
Findings: From 120 cases, 77% (92 cases) were females and 23% (28 cases) males (F: M=3.3). Mean follow up period was 56±32 months and mean age at the time of manifesting disease 10.34±2.9 years. Mortality rate was 10% (12 cases) in our investigation. Musculoskeletal involvement showed significant difference between various age groups (P<0.01), that was more frequent in group of 7 years and older. Frequency of oral ulcer and ophthalmic involvement in boys was significantly higher than in girls (P<0.05). Frequency of cardiovascular involvement (P<0.01) and renal involvement (P<0.01) was significantly higher in the patients who had no remission. There was a significant association between mortality rate and cardiac (P<0.02, OR=4.9), pulmonary (P<0.01, OR=10.167) and liver (P<0.05, OR=1.19) involvement.
Conclusion: In our investigation 1-year survival rate was 97% and 5-year survival rate 89%. Liver, cardiac and pulmonary involvements have an association with higher mortality in JSLE patients.

 
Keyword(s): SYSTEMIC LUPUS ERYTHEMATOSUS, MORTALITY, MORBIDITY, JUVENILE, CHILDREN, IRAN
 
 
References: 
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Click to Cite.
APA: Copy

TAVANGAR RAD, F., & ZIAEE, V., & MORADINEJAD, M., & TAHGHIGHI, F. (2014). MORBIDITY AND MORTALITY IN IRANIAN CHILDREN WITH JUVENILE SYSTEMIC LUPUS ERYTHEMATOSUS. IRANIAN JOURNAL OF PEDIATRICS, 24(4), 365-370. https://www.sid.ir/en/journal/ViewPaper.aspx?id=408054



Vancouver: Copy

TAVANGAR RAD FARIBA, ZIAEE VAHID, MORADINEJAD MOHAMMAD HASSAN, TAHGHIGHI FATEMEH. MORBIDITY AND MORTALITY IN IRANIAN CHILDREN WITH JUVENILE SYSTEMIC LUPUS ERYTHEMATOSUS. IRANIAN JOURNAL OF PEDIATRICS. 2014 [cited 2021May06];24(4):365-370. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408054



IEEE: Copy

TAVANGAR RAD, F., ZIAEE, V., MORADINEJAD, M., TAHGHIGHI, F., 2014. MORBIDITY AND MORTALITY IN IRANIAN CHILDREN WITH JUVENILE SYSTEMIC LUPUS ERYTHEMATOSUS. IRANIAN JOURNAL OF PEDIATRICS, [online] 24(4), pp.365-370. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408054.



 
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