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Paper Information

Journal:   IRANIAN JOURNAL OF PEDIATRICS   AUGUST 2014 , Volume 24 , Number 4; Page(s) 418 To 422.
 
Paper: 

CAN PROCALCITONIN REDUCE UNNECESSARY VOIDING CYSTOURETEROGRAPHY IN CHILDREN WITH FIRST FEBRILE URINARY TRACT INFECTION?

 
 
Author(s):  HALIMI ASL ALI ASGHAR, HOSSEINI AMIR HOSSEIN*, NABAVIZADEH POUNEH
 
* DEPARTMENT OF PEDIATRICS. SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Objective: Recently, new predictors of vesicoureteral reflux (VUR) in children with a first febrile UTI such as Procalcitonin (PCT) were introduced as selective approaches for cystography. This study wants to show the capability of PCT in predicting presence of VUR at the first febrile UTI in children.
Methods: Patients between 1 month and 15 years of age with febrile UTI were included in this prospective study. PCT values were measured through a semi-quantitative method in four grades comprising values less than 0.5, 0.5-2.0, 2.0-10.0 and above 10.0 ng/ml. The independence of PCT levels in predicting VUR were assessed after adjustment for all potential confounders using a logistic-regression model.
Findings: A total of 68 patients, 54 (79.4%) girls and 14 (20.6%) boys were evaluated. PCT level demonstrated a significant difference between patients with positive VUR and those with negative VUR (P=0.012). To calculate the independent factors that may predict the presence of VUR, all included variables were adjusted for age and sex. Results of logistic regression showed that a PCT level between 2.0 and 10.0 ng/mL could independently predict presence of VUR (Odds ratio=6.11, CI 95%=1.22-30.77, P=0.03).
Conclusion: Our finding in this study showed that readily available semi-quantitative measures for PCT are feasible for detecting patients with VUR. We suggest that in semi-quantitative measurements of PCT, levels between 2.0 and 10.0 ng/ml could be an independent predictor of positive VUR.

 
Keyword(s): URINARY TRACT INFECTION, PROCALCITONIN LEVELS, VESICOURETERAL REFLUX, VOIDING CYSTOURETHROGRAM
 
References: 
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