Paper Information

Journal:   IRANIAN JOURNAL OF PEDIATRICS   AUGUST 2014 , Volume 24 , Number 4; Page(s) 359 To 364.
 
Paper: 

DISTRIBUTION AND PROTECTIVE ROLE OF HLAB40 IN IRANIAN PATIENTS WITH KAWASAKI DISEASE; A REPORT FROM SOUTHERN IRAN

 
 
Author(s):  AJAMI GHOLAMHOSSEIN, AFLAKI KHASHAYAR, ALYASIN SOHEILA, GHARESI FARD BEHROUZ, BORZOUEE MOHAMMAD, AMOOZGAR HAMID*
 
* CARDIAC AND NEONATOLOGY RESEARCH CENTER, SHIRAZ UNIVERSITY OF MEDICAL SCIENCES, SHIRAZ, IRAN
 
Abstract: 

Objective: Kawasaki disease (KD) clinically presents as a systemic vasculitis syndrome with significant cardiovascular involvement. With different incidence among different ethnic groups, the role of certain human leukocyte antigens and their products has been considered as a crucial predisposing factor in the immune responses in this disease.
Methods: We determined the distribution of human leukocyte antigens type B for 90 Iranian patients with Kawasaki disease in order to evaluate a possible association between these antigens and this disease in our area. We used the polymerase chain reaction (PCR) sequence specific primers (PCR-SSP) technique for antigen typing. Distribution of these antigens for 89 healthy Iranians used as control.
Findings: While 7 (3.9%) of our patients were positive for human leukocyte antigen type B 40*, there were 18 (10.1%) subjects from the control group who had this antigen with statistically significant difference between patients and control group (CI=95%, RR=1.15 and P=0.02). Data were analyzed by Pearson chi-square test and Fisher's exact test. SPSS version 15 was used for statistical analysis and a P value less than 0.05 considered statistically significant Conclusion: The presence of higher frequency of allele type-B40* in the control group may represent a protective role for this antigen with resultant decreased susceptibility to KD in our area.

 
Keyword(s): KAWASAKI DISEASE, GENE PROTECTION, HUMAN LEUKOCYTE ANTIGENS, HLA- B40* ALLELE
 
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