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Paper Information

Journal:   IRANIAN JOURNAL OF PATHOLOGY (IJP)   WINTER 2015 , Volume 10 , Number 1; Page(s) 35 To 40.
 
Paper: 

THE VALUE OF BRONCHOALVEOLAR LAVAGE IN THE DIAGNOSIS OF SPUTUM SMEAR-NEGATIVEPULMONARY TUBERCULOSIS

 
 
Author(s):  NIKBAKHSH NOVIN, BAYANI MASOMEH, SIADATI SEPIDEH*
 
* DEPT. OF PATHOLOGY, BABOL UNIVERSITY OF MEDICAL SCIENCES, BABOL, IRAN
 
Abstract: 

Background and Objectives: Sputum smear staining for acid-fast bacilli is initial approach to the diagnosis of pulmonary tuberculosis (PTB) but more than 50% of cases are sputum smear-negative. This study was aimed to investigate the diagnostic value of fiberoptic bronchoscopy (FOB) guided bronchoalveolar lavage (BAL) in patients suspected to have tuberculosis.
Methods: This prospective cross-sectional study was carried out on 290 sputum smear-negative patients who were clinically suspicious for PTB in 2006-12. All patients were subjected to FOB andBAL, then BAL specimens stained and cultured.
Results: Of the 290 patients, 173 cases (59.7%) were men and 117 cases (40.3%) were women with the age of 52.6±19.1 years (ranged 20-76 years). Of the total 290 BAL specimens, 110 specimens (38%) were positive for acid-fast bacilli. Sensitivity, specificity, PPV and NPV was 60%, 91%, 89% and 64%, respectively. Also, LR+and LR- was 64.6% and 0.44%, respectively.
Conclusion: FOB guided BAL is a reliable, rapid and useful method for establishing the diagnosis of smear negative PTB with minimal complications.

 
Keyword(s): PULMONARY TUBERCULOSIS, BRONCHOALVEOLAR LAVAGE, SPUTUM
 
References: 
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