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Paper Information

Journal:   JOURNAL OF CHEMICAL HEALTH RISKS (JCHR)   2014 , Volume 4 , Number 4; Page(s) 17 To 24.
 
Paper: 

SPECTROFLUORIMETRIC DETERMINATION OF DOXORUBICIN IN SPIKED SERUM AND URINE SAMPLES

 
 
Author(s):  MANZOORI JAMSHID L.*, ABULHASSANI JAFAR, NIAEI NAVID
 
* DEPARTMENT OF CHEMISTRY, FACULTY OF SCIENCE, TABRIZ BRANCH, ISLAMIC AZAD UNIVERSITY, TABRIZ, IRAN
 
Abstract: 

A simple spectrofluorimetric method is described for the determination of doxorubicin (DXR) based on its quenching effect on the fluorescence intensity of Tb3+- deferasirox (DFX) complex as a fluorescent probe. The excitation and emission wavelengths were 328 and 545 nm, respectively. The effects of pH, time, order of addition of reagents, concentrations of Tb3+ and DFX and the buffer volume on the quenched fluorescence intensity were investigated and optimized. In the optimum conditions, the decrease of the fluorescence intensity of the system showed a good linear relationship with the concentration of DXR in the range of 20-1000 mg L-1, with a correlation coefficient 0.998. The detection limit (3s) was 6.1 mg L-1 and the relative standard deviation for four replicate determinations of different concentrations of DXR was in the range of 1.7-4.4%. The procedure was successfully applied to the determination of doxorubicin in urine and serum samples.

 
Keyword(s): SPECTROFLUORIMETRY, TERBIUM-SENSITIZED, DEFERASIROX, DOXORUBICIN
 
 
References: 
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Click to Cite.
APA: Copy

MANZOORI, J., & ABULHASSANI, J., & NIAEI, N. (2014). SPECTROFLUORIMETRIC DETERMINATION OF DOXORUBICIN IN SPIKED SERUM AND URINE SAMPLES. JOURNAL OF CHEMICAL HEALTH RISKS (JCHR), 4(4), 17-24. https://www.sid.ir/en/journal/ViewPaper.aspx?id=407997



Vancouver: Copy

MANZOORI JAMSHID L., ABULHASSANI JAFAR, NIAEI NAVID. SPECTROFLUORIMETRIC DETERMINATION OF DOXORUBICIN IN SPIKED SERUM AND URINE SAMPLES. JOURNAL OF CHEMICAL HEALTH RISKS (JCHR). 2014 [cited 2021May09];4(4):17-24. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=407997



IEEE: Copy

MANZOORI, J., ABULHASSANI, J., NIAEI, N., 2014. SPECTROFLUORIMETRIC DETERMINATION OF DOXORUBICIN IN SPIKED SERUM AND URINE SAMPLES. JOURNAL OF CHEMICAL HEALTH RISKS (JCHR), [online] 4(4), pp.17-24. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=407997.



 
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