Paper Information

Journal:   IRANIAN JOURNAL OF PEDIATRICS   AUGUST 2014 , Volume 24 , Number 4; Page(s) 411 To 417.
 
Paper: 

EPICARDIAL ADIPOSITY IN CHILDREN WITH OBESITY AND METABOLIC SYNDROME

 
Author(s):  EREN ERDAL*, KOCA BULENT, TURE MEHMET, GUZEL BULENT
 
* HARRAN UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF PEDIATRIC ENDOCRINOLOGY, 63300, YENISEHIR/SANLIURFA, TURKEY
 
Abstract: 

Objective: Obesity increases cardiac diseases by increasing tendency to atherosclerosis. Our aim was to define epicardial adipose tissue thickness, and its related factors in obese children.
Methods: Total of 94 patients were divided into obesity with metabolic syndrome (MS) (n=30), obesity without MS (n=33), and control (n=31) groups. Auxological values with fasting glucose, fasting insulin, alanine transaminase, serum lipid levels, and high sensitive C-reactive protein levels were evaluated. Epicardial adipose tissue thickness, interventricular septum thickness and left ventricular mass were measured by echocardiography.
Findings: Weight, body mass index, waist circumference, insulin, alanine transaminase, and high sensitive C-reactive protein values were markedly higher in obesity group when compared with controls (P<0.001). Epicardial adipose tissue thickness was 0.64±0.23 cm in obesity with MS; 0.60±0.20 cm in obesity without MS, and 0.27±0.12 cm in control group (P<0.001). Interventricular septum thickness and left ventricular mass values were markedly high in obesity without MS group (P<0.001 and P=0.002).
Conclusion: Our study has indicated that obesity has unfavorable effects on heart starting in the adolescence.

 
Keyword(s): ADIPOSE TISSUE, INSULIN RESISTANCE, OBESITY, METABOLIC SYNDROME, CARDIOVASCULAR DISEASES, ADOLESCENCE
 
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