Paper Information

Journal:   INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)   OCTOBER 2014 , Volume 12 , Number 4; Page(s) 1 To 4.
 
Paper: 

DESMOPRESSIN LYOPHILISATE FOR THE TREATMENT OF CENTRAL DIABETES INSIPIDUS: FIRST EXPERIENCE IN VERY YOUNG INFANTS

 
Author(s):  WAELE KATHLEEN DE, COOLS MARTINE, DE GUCHTENAERE ANN, DE WALLE JOHAN VAN, RAES ANN, AKEN SARA VAN, COEN KRIS DE, VANHAESEBROUCK PIET, SCHEPPER JEAN DE*
 
* DEPARTMENT OF PEDIATRICS, DIVISION OF PAEDIATRIC ENDOCRINOLOGY, UNIVERSITY HOSPITAL GHENT, GHENT, BELGIUM
 
Abstract: 

Introduction: In neonates and small infants, early diagnosis of central diabetes insipidus (CDI) and treatment with desmopressin in low doses (avoiding severe hypo- or hypernatremia) are important to prevent associated high morbidity and mortality in this particular age group.
Case Presentation: We described pharmacokinetic and pharmacodynamic results of the use of recently launched oral desmopressin lyophilisate (Minirin Melt®) in two infants with CDI, diagnosed at the age of 12 and 62 days, respectively. We observed that a starting dose of 60 ?g of Minirin Melt® in the first case resulted in a pharmacokinetic profile largely exceeding the reference frame observed in children with nocturnal enuresis, while a dose of 15 ?g in the second case resulted in acceptable concentrations. After initial dose adjustments, administration of sublingual lyophilisate resulted in rather stable serum sodium concentrations.
Conclusions: Using Minirin Melt® in infants with CDI appears to be effective, easy to use and well tolerated.

 
Keyword(s): DESMOPRESSIN, DIABETES INSIPIDUS, INFANT, HYPERNATREMIA
 
References: 
  • ندارد
 
  pdf-File tarjomyar Yearly Visit 48
 
Latest on Blog
Enter SID Blog