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Paper Information

Journal:   INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)   JULY 2014 , Volume 12 , Number 7; Page(s) 493 To 498.
 
Paper: 

OVARIAN STIMULATION MEDICATIONS AND PATIENTS' RESPONSES AS PROGNOSTIC FACTORS IN IUI-TREATED INFERTILE SAUDI PATIENTS

 
 
Author(s):  M.ISA AHMED*, ABU RAFEA BASIM, AL ASIRI SAHEL, AL MOTAWA JOHARA, ALMADY KHALID, ALWAZNAH RAHEEK
 
* DEPARTMENT OF OBSTETRICS AND GYNECOLOGY, KING SAUD UNIVERSITY, COLLEGE OF MEDICINE, ASSISTED CONCEPTION UNIT, RIYADH 11472, SAUDI ARABIA
 
Abstract: 

Background: Intrauterine Insemination (IUI) remains the first thought of infertility treatment.
Objective: To compare the stimulation effects and Pregnancy rate (PR) outcomes of two ovulation induction (OI) medications, human-derived menopausal gonadotrophins (hMGH), Merional (MER), and recombinant follicular stimulating hormone (rFSH), Puregon (PUR), in a cohort of Saudi infertile patients, for better predictability of treatment results.
Materials and Methods: During a 24-month period, 296 women underwent IUI single treatments. PR’s were correlated with the type of stimulation medication that were prospectively and randomly assigned to each patient, and with the number and size of maturing follicles detected on the hCG injection day.
Results: MER and PUR needed comparable number of days (9.26
±4.74 and 9.73±6.27 respectively) before follicles were ready for IUI, although the average amount used from MER, 1199.90 IU, was about double that was used from PUR, 621.08 IU. The overall PR in case of PUR however was nearly double that of MER, 13.28% and 7.14% respectively. The best PR, 16.22%, occurred when the follicles matured within 12-13 days. Three follicles of at least 15-mm diameter on the hCG day had better PR’s than one or two, however when the follicles’ diameters were at least 18-mm, PR was significantly higher, (p=0.013).
Conclusion: MER and PUR had comparable stimulation effects; however PUR had noticeably higher PR. The best PR occurred when the follicles matured within 12-13 days. PR in case of three maturing follicles on the hCG day was better than only one or two, and significantly better when their diameters were at least 18 mm.

 
Keyword(s): ARTIFICIAL INSEMINATION, OVULATION INDUCTION, OVARIAN FOLLICLES, PREGNANCY RATE
 
 
References: 
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Click to Cite.
APA: Copy

M.ISA, A., & ABU RAFEA, B., & AL ASIRI, S., & AL MOTAWA, J., & ALMADY, K., & ALWAZNAH, R. (2014). OVARIAN STIMULATION MEDICATIONS AND PATIENTS' RESPONSES AS PROGNOSTIC FACTORS IN IUI-TREATED INFERTILE SAUDI PATIENTS. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 12(7), 493-498. https://www.sid.ir/en/journal/ViewPaper.aspx?id=407971



Vancouver: Copy

M.ISA AHMED, ABU RAFEA BASIM, AL ASIRI SAHEL, AL MOTAWA JOHARA, ALMADY KHALID, ALWAZNAH RAHEEK. OVARIAN STIMULATION MEDICATIONS AND PATIENTS' RESPONSES AS PROGNOSTIC FACTORS IN IUI-TREATED INFERTILE SAUDI PATIENTS. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE). 2014 [cited 2021May10];12(7):493-498. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=407971



IEEE: Copy

M.ISA, A., ABU RAFEA, B., AL ASIRI, S., AL MOTAWA, J., ALMADY, K., ALWAZNAH, R., 2014. OVARIAN STIMULATION MEDICATIONS AND PATIENTS' RESPONSES AS PROGNOSTIC FACTORS IN IUI-TREATED INFERTILE SAUDI PATIENTS. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), [online] 12(7), pp.493-498. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=407971.



 
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