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Paper Information

Journal:   INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)   OCTOBER 2014 , Volume 12 , Number 4; Page(s) 1 To 4.
 
Paper: 

IMPACT OF PLASMA GLUCOSE LEVEL AT THE TIME OF FLUOROD EOXYGLUCOSE ADMINISTRATION ON THE ACCURACY OF FDG-PET/CT IN THE DIAGNOSIS OF PANCREATIC LESIONS

 
 
Author(s):  HAMIDIAN JAHROMI ALIREZA, FALLAHZADEH MOHAMMAD KAZEM, TAKALKAR AMOL, SHENG JEAN, ZIBARI GAZI, SHOKOUH AMIRI HOSEIN*
 
* JOHN C. MCDONALD REGIONAL TRANSPLANT CENTER, WILLIS KNIGHTON HEALTH SYSTEM, SHREVEPORT, LOUISIANA, USA
 
Abstract: 

Background: High fasting plasma glucose (FPG) levels before fluorodeoxyglucose (FDG) administration for positron emission tomography/computed tomography (PET/CT) might affect the accuracy of 18-fluoro-deoxy-glucose-positron emission tomography-computed tomography (FDG-PET/CT) in diagnosis of pancreatic lesions. Current guidelines require FPG levels of<200 mg/dL before FDG administration, however, the literature on the effect of FPG levels of<200 mg/dL on the accuracy of FDG-PET/CT is scarce.
Objectives: The aim of this study was to evaluate the effect of FPG levels of<200 mg/dL on the accuracy of FDG-PET/CT in diagnosis of pancreatic lesions.
Patients and Methods: In this retrospective study, 161 patients who had FDG-PET/CT for initial diagnosis of pancreatic lesions were included. Fasting plasma glucose levels before FDG administration were recorded. Accuracy of FDG-PET/CT in diagnosis of pancreatic lesions was compared between patients who were normoglycemic (FPG<126 mg/dL) and hyperglycemic (126
£ FPG<200 mg/dL).
Results: Thirty-four patients were hyperglycemic and 127 normoglycemic. Sensitivity, specificity, positive predictive value and negative predictive value of FDG-PET/CT were 90%, 88%, 87% and 91% in normoglycemic and 82%, 92%, 95% and 73% in hyperglycemic patients, respectively. Overall, the accuracy was higher in normoglycemic than hyperglycemic patients (89% vs.85%).
Conclusions: Accuracy of FDG-PET/CT for primary diagnosis of pancreatic lesions is higher in patients with FPG levels<126 mg/dL than in patients with FPG levels between 126 and 200 mg/dL.

 
Keyword(s): CANCER, DIAGNOSIS, GLUCOSE, PANCREAS, POSITRON EMISSION TOMOGRAPHY
 
References: 
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