Paper Information

Journal:   JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)   4TH WEEK SEPTEMBER 2014 , Volume 32 , Number 295; Page(s) 1 To 19.
 
Paper: 

BRUCELLA: PATHOGENESIS, IMMUNE SYSTEM RESPONSE AND VACCINE

 
Author(s):  GHASEMI AMIR*, RANJBAR REZA
 
* DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY, FACULTY OF MEDICINE, KASHAN UNIVERSITY OF MEDICAL SCIENCES, KASHAN, IRAN
 
Abstract: 

Bacteria of the genus Brucella are intracellular pathogens capable of surviving and replicating within macrophages of mammalian hosts. Resistance to killing in professional phagocytic cells controls survival and chronic infection. Recent advances have shed light on virulence factors and host functions involved at various stages of the Brucella intracellular life cycle. This review focuses on how this pathogen uses multiple strategies to circumvent macrophage defense mechanisms and generate an organelle permissive for replication. In addition, we discuss about host immune responses to Brucella and new strategies are used to produce an efficient vaccine against Brucella infection.

 
Keyword(s): BRUCELLA, VACCINE, PATHOGENESIS, MACROPHAGE
 
References: 
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