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Paper Information

Journal:   RESEARCH IN PHARMACEUTICAL SCIENCES (RPS)   DECEMBER 2014 , Volume 9 , Number 6; Page(s) 421 To 429.
 
Paper: 

EFFECT OF THE HYDROALCOHOLIC EXTRACT AND JUICE OF PRUNUS DIVARICATA FRUIT ON BLOOD GLUCOSE AND SERUM LIPIDS OF NORMAL AND STREPTOZOTOCININDUCED DIABETIC RATS

 
 
Author(s):  MINAIYAN M., GHANNADI A., MOVAHEDIAN A., RAMEZANLOU P.*, OSOOLI F.S.
 
* STUDENT'S RESEARCH COMMITTEE OF PHARMACY, SCHOOL OF PHARMACY AND PHARMACEUTICAL SCIENCES, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, I.R. IRAN
 
Abstract: 

Prunus divaricata (Alloocheh) is a small tree cultivating in Iran, Middle East and central Asia. Prunus genus has many species with anti-oxidant, anti-hyperlipidemia and anti-hyperglycemia effects. In the present study the anti-diabetic and anti-hyperlipidemic effects of P. divaricata fruits were examined in normal and streptozotocin (STZ)-induced diabetic rats. Both groups, control and reference rats received normal saline and glibenclamide respectively. Test groups were treated with Prunus freeze dried juice (PFDJ, 200, 400, 800 mg/kg) and Prunus freeze dried extract (PFDE, 100, 200, 400 mg/kg) started at the 3rd day of the experiment and continued for 27 days thereafter. Weight changes of animals were checked periodically. Fasting blood glucose (FBG) level as well as serum triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterol were determined. Different treatments had no significant effect on body weight increments of normal rats, while in diabetic rats, PFDJ (800 mg/kg) and PFDE (400 mg/kg) opposed with weight loss. In acute phase of experiment (0-8 h of 3rd day), none of tested fractions were effective in reducing FBG and serum lipids of normal rats. During the sub-acute phase (13th and 30th days) however, the greatest test doses of PFDJ (800 mg/kg) and PFDE (400 mg/kg) induced hypoglycema. In diabetic groups, PFDJ and PFDE, at all test doses, could diminish FBG during sub-acute phase of the experiment. In addition, PFDJ and PFDE at most examined doses could diminish TG significantly and they were also effective on cholesterol derivatives in different magnitude.

 
Keyword(s): PRUNUS DIVARICATA, DIABETES, HYPERLIPIDEMIA, STREPTOZOTOCIN, RATS
 
 
References: 
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APA: Copy

MINAIYAN, M., & GHANNADI, A., & MOVAHEDIAN, A., & RAMEZANLOU, P., & OSOOLI, F. (2014). EFFECT OF THE HYDROALCOHOLIC EXTRACT AND JUICE OF PRUNUS DIVARICATA FRUIT ON BLOOD GLUCOSE AND SERUM LIPIDS OF NORMAL AND STREPTOZOTOCININDUCED DIABETIC RATS. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), 9(6), 421-429. https://www.sid.ir/en/journal/ViewPaper.aspx?id=407842



Vancouver: Copy

MINAIYAN M., GHANNADI A., MOVAHEDIAN A., RAMEZANLOU P., OSOOLI F.S.. EFFECT OF THE HYDROALCOHOLIC EXTRACT AND JUICE OF PRUNUS DIVARICATA FRUIT ON BLOOD GLUCOSE AND SERUM LIPIDS OF NORMAL AND STREPTOZOTOCININDUCED DIABETIC RATS. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS). 2014 [cited 2021May15];9(6):421-429. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=407842



IEEE: Copy

MINAIYAN, M., GHANNADI, A., MOVAHEDIAN, A., RAMEZANLOU, P., OSOOLI, F., 2014. EFFECT OF THE HYDROALCOHOLIC EXTRACT AND JUICE OF PRUNUS DIVARICATA FRUIT ON BLOOD GLUCOSE AND SERUM LIPIDS OF NORMAL AND STREPTOZOTOCININDUCED DIABETIC RATS. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), [online] 9(6), pp.421-429. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=407842.



 
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