Paper Information

Journal:   INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)   JULY 2014 , Volume 12 , Number 7; Page(s) 467 To 470.
 
Paper: 

RECURRENT IVF FAILURE AND HEREDITARY THROMBOPHILIA

 
 
Author(s):  SAFDARIAN LEILA, NAJMI ZAHRA, ALEYASIN ASHRAF, AGHAHOSSEINI MARZIEH, RASHIDI MANDANA*, ASADOLLAH SARA
 
* MANDANA RASHIDY, DEPARTMENT OF INFERTILITY, SHAHID AKBAR-ABADI HOSPITAL, MOLAVI ST., TEHRAN, IRAN
 
Abstract: 

Background: The largest percentage of failed invitro fertilization (IVF) cycles, are due to lack of implantation. As hereditary thrombophilia can cause in placentation failure, it may have a role in recurrent IVF failure.
Objective: Aim of this case-control study was to determine whether hereditary thrombophilia is more prevalent in women with recurrent IVF failures.
Materials and Methods: Case group comprised 96 infertile women, with a history of recurrent IVF failure. Control group was comprised of 95 healthy women with proven fertility who had conceived spontaneously. All participants were assessed for the presence of inherited thrombophilias including: factor V Leiden, methilen tetrahydrofolate reductase (MTHFR) mutation, prothrombin mutation, homocystein level, protein S and C deficiency, antithrombin III (AT-III) deficiency and plasminogen activator inhibitor-1 (PAI-1) mutation. Presence of thrombophilia was compared between groups.
Results: Having at least one thrombophilia known as a risk factor for recurrent IVF failure (95% CI=1.74-5.70, OR=3.15, p=0.00). Mutation of factor V Leiden (95% CI=1.26-10.27, OR=3.06, P=0.01) and homozygote form of MTHFR mutation (95% CI=1.55-97.86, OR=12.33, p=0.05) were also risk factors for recurrent IVF failure. However, we could not find significant difference in other inherited thrombophilia’s.

 
Keyword(s): RECURRENT IMPLANTATION FAILURE, IN VITRO FERTILIZATION, HEREDITARY THROMBOPHILIA
 
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