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Paper Information

Journal:   RESEARCH IN PHARMACEUTICAL SCIENCES (RPS)   DECEMBER 2014 , Volume 9 , Number 6; Page(s) 407 To 420.
 
Paper: 

THE EFFECTS OF TECHNICAL AND COMPOSITIONAL VARIABLES ON THE SIZE AND RELEASE PROFILE OF BOVINE SERUM ALBUMIN FROM PLGA BASED PARTICULATE SYSTEMS

 
 
Author(s):  TAGHIPOUR B., YAKHCHALI M., HARIRIAN I., TAMADDON A.M., MOHAMMADI SAMANI S.*
 
* CENTER FOR NANOTECHNOLOGY IN DRUG DELIVERY, FACULTY OF PHARMACY, SHIRAZ UNIVERSITY OF MEDICAL SCIENCES, SHIRAZ, I.R. IRAN
 
Abstract: 

Double emulsion solvent evaporation technique is one of the most attractive methods used to prepare micro and nanoparticles in pharmaceutical areas of interest, but because of the effects of many formulation factors on the size and release behavior of the fabricated particles, optimization of the formulation factors is needed. In this study various parameters including technical and compositional variables were considered to achieve an optimized formulation with desire characteristics especially size and the release profiles, using high shear homogenizer. In this regard, bovine serum albumin (BSA) was used as the model protein and double emulsion was formed with the addition of Tween 80 and Span 80 as surfactants for inner aqueous phase and oil phase, respectively. Hydroxypropyl beta cyclodextrin was used as protein stabilizer. After optimization steps, composite nanoparticles (core-shell) were made based on optimized formulation by hyaluronic acid as shell and poly lactic-co-glycolic acid (PLGA) as core material. Formulation of the BSA loaded PLGA nanoparticles using core shell strategy improved the release pattern of the BSA and diminished burst release. The final composite nanoparticles had the particle size of about 160 nm and 70 % of the loaded BSA was released during 14 days and the release data was better fitted to zero order release kinetics.

 
Keyword(s): PROTEIN, DRUG DELIVERY, BIODEGRADABLE, PLGA, NANOCOMPOSITE
 
 
References: 
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Click to Cite.
APA: Copy

TAGHIPOUR, B., & YAKHCHALI, M., & HARIRIAN, I., & TAMADDON, A., & MOHAMMADI SAMANI, S. (2014). THE EFFECTS OF TECHNICAL AND COMPOSITIONAL VARIABLES ON THE SIZE AND RELEASE PROFILE OF BOVINE SERUM ALBUMIN FROM PLGA BASED PARTICULATE SYSTEMS. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), 9(6), 407-420. https://www.sid.ir/en/journal/ViewPaper.aspx?id=407830



Vancouver: Copy

TAGHIPOUR B., YAKHCHALI M., HARIRIAN I., TAMADDON A.M., MOHAMMADI SAMANI S.. THE EFFECTS OF TECHNICAL AND COMPOSITIONAL VARIABLES ON THE SIZE AND RELEASE PROFILE OF BOVINE SERUM ALBUMIN FROM PLGA BASED PARTICULATE SYSTEMS. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS). 2014 [cited 2021May06];9(6):407-420. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=407830



IEEE: Copy

TAGHIPOUR, B., YAKHCHALI, M., HARIRIAN, I., TAMADDON, A., MOHAMMADI SAMANI, S., 2014. THE EFFECTS OF TECHNICAL AND COMPOSITIONAL VARIABLES ON THE SIZE AND RELEASE PROFILE OF BOVINE SERUM ALBUMIN FROM PLGA BASED PARTICULATE SYSTEMS. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), [online] 9(6), pp.407-420. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=407830.



 
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